Clinical Research Of Bile Reflux Gastritis Of Syndrome Of Intermingled Heat And Cold With The Treatment Of Anwei Decoction

Objective: To observe and evaluate the clinical curative effect of Anwei Decoction syndrome of intermingled heat and cold of bile reflux gastritis,provide a reference for the further understanding of bile reflux gastritis pathogenesis and clinical medicine,and provide a new basis for clinical application and research development of Anwei Decoction.Methods: 40 patients were selected from whom were diagnosed with syndrome of intermingled heat and cold of bile reflux gastritis by Department of Gastroenterology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine inpatient ward during Dec.2014 to Sep.2016.Divided the 40 patients into treatment group and control group according to random number table method,20 cases in each group.The treatment group was treated with oral administration of Chinese herbal compound Anwei Decoction treatment,and the control group was treated with Itopride Hydrochloride Dispersible Tablets combined with Hydrotalcite Tablets treatment.The two groups of patients were 2 weeks for 1 courses of treatment,continuous treatment of 2 courses,and clinical cure patients for a period of 3 months of follow-up.Analysis of TCM Syndromes of two groups were compared,the overall clinical efficacy of electronic gastroscope curative effect,integral,stomach 24 hours bile monitoring and Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD-17)score of 17,and to observe the safety and long-term efficacy of drugs.Result: 1.After analysis and comparison,there were no significant differences in gender,age,course of disease and bile reflux degree between the two groups(P>0.05).2.There was no significant difference between the two groups before and after treatment(P>0.05).After 2 courses of treatment,the two groups of patients with different TCM syndrome points were reduced,and the treatment group of TCM syndrome score significantly better than the control group(P<0.05).3.The treatment group compared with the control group and the total symptom score of patients before treatment were decreased,and the patients in the treatment group after treatment the total symptom score decreased significantly better than the control group(P<0.05).4.The 20 patients were recovered in 8 cases of the treatment group,5 cases were cured,5 cases effective,2 cases ineffective,the total effective rate was 90%;control group 20 patients were cured in 3 cases,4 cases were cured,7 cases effective,6 cases ineffective,the total effective rate was 70%.The curative effect of the treatment group was better than that of the control group(P<0.05).5.The treatment group 7 cases were cured 20 cases of patients in clinic,5 cases were markedly effective,6 cases effective,2 cases ineffective,the total efficiency was 90%;the control group 3 cases were cured 20 cases of patients in clinic,3 cases were cured,6cases effective,8cases ineffective,the total effective rate was 60%.The clinical efficacy of the treatment group was better than the control group(P<0.05).6.The treatment group and control group after the treatment of bilirubin absorption value is more than 0.14 of the total time percentage,24 hours of bile reflux episodes,bile reflux,5 minutes and the number of the longest duration of reflux compared with before treatment were lower than or(and)less than before treatment,and the patients in the treatment group were improved obviously the control group(P<0.05).7.The patients in the two groups before and after treatment,HAMA and HAMD-17 scores in two groups of patients with HAMA and HAMD-17 scores had no statistically significant difference between before treatment was not statistically significant(P>0.05),the patients in the treatment group after treatment HAMA and HAMD-17 scores were significantly lower than the control group(P<0.05).8.The two groups of patients during the treatment showed no adverse reaction,difference between the two groups was not statistically significant(P>0.05).9.To schedule after the treatment of two groups of clinical cured patients were followed up for 2 months,1 cases of 7 patients in the treatment group were followed up for disease recurrence,the recurrence rate was 14.29%;3 patients in control group were 2 cases of recurrence,the recurrence rate is 66.67%.The 2 test,the recurrence rate of control group was significantly higher than the treatment group(P<0.05).Conclusion:Anwei Decoction in the treatment of the syndrome of intermingled heat and cold of bile reflux gastritis has clinical curative effect,no obvious side effects,good safety,and can improve the patient’s anxiety and depression to a certain extent,improve the quality of life of patientsit,is worthy of clinical popularization and application.