An Analysis Of Risk Factors For Early Recurrence Of 689 Patients Receiving Liver Resection For Hepatocellular Carcinoma

Objective:the purpose of this study is to investigate which variable is correlated with early recurrence in patients with hepatocellular carcinoma after hepatectomy(HCC).Methods:the medical records of 1020 patients who received haptic resection for HCC were initially admitted during January 2005 and June 2012 in the first department of Surgery,the First Affiliated Hospital of Guangxi Medical University and the Department of Hepatobiliary Gland Surgery,the People’s Hospital of Guangxi Zhuang Autonomous Region,were retrospectively analyzed.A total of 689 patients were included in this study.The enrolled patients were divided into two groups according to the time from initial resection to recurrence: early recurrence group(≤2 years,n=459)and late recurrence group(>2years,n=230).The clinicopathological variables were assessed by logistic regression.Results:Univariate analysis factor analysis showed that TNM stage,tumor size(≥ 5cm),tumor number(≥ 2),tumor capsule(incomplete),portal vein tumor thrombus,vascular invasion,histological grade,perioperative blood transfusion,alpha foetal protein(≥400ng/ml),aspartate aminotransferase(> 80U/L),neutrophil to lymphocyte ratio(NLR ≥ 2.31),lymphocyte to monocyte ratio(LMR≤3.21),gutamyl transpeptidase(> 100U/L)were associated with early recurrence of HCC(P<0.05).Multivariate analysis showed that tumor size(≥ 5cm),tumor number(≥2),portal vein tumor thrombus,vascular invasion,histological grade,alpha fetoprotein(≥400ng/ml),NLR(≥ 2.31)were independent risk factors for early postoperative recurrence after HCC(P<0.05).Conclusions:Postoperative early recurrence of HCC is related to many factors.tumor size(≥ 5cm),tumor number(≥2),portal vein tumor thrombus,vascular invasion,histological grade,alpha fetoprotein(≥400ng/ml),NLR(≥ 2.31)were identified as independent risk factors of early recurrence for patients with HCC after hepatic resection.