Comparative Study Of The Efficacy Of Adjuvant Transarterial Chemoembolization And Transarterial Embolization In Patients With Hepatocellular Carcinoma After Radical Resection

ObjectiveTo compare the effect of transarterial chemoembolization(TACE)and transarterial embolization(TAE)on the prognosis of hepatocellular carcinoma(HCC)patients after radical resection.MethodsFrom April 2010 to April 2016 in Shandong Cancer Hospital,a total of 136 patients with HCC who received LR were enrolled.These patients did not receive other treatment before radical resection.The standard of “radical resection” based on the Grade II radical resection accoding to “primary liver cancer diagnosis and treatment guidelines ”which promulgated by People’s Republic of China Ministry of Health in 2011.All patients were followed up to February 28,2017.We defined 36 patients who received only LR as group A,30 patients who received postoperative TACE therapy as group B,70 patients who received postoperative TAE therapy as group C.The prognosis and influencing factors were analyzed according to the clinical data of patients.ResultsThere were no significant differences in gender,age,tumor size,alpha fetoprotein(AFP),liver function Child-pugh grade,albumin(ALB),total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma glutamyl transpeptidase(GGT)of the three groups(P> 0.05).The Barcelona clinical liver cancer(BCLC)stage of group A was higher than that of group B and group C(P=0.012,P<0.001).The 1-,2-and 3-years Overall survival(OS)rate were 75.0%,75.0%,75.0% in the group A respectively,93.3%,90.0%,86.7% in the group B respectively,and 91.4%,87.1%,78.6% in the group C respectively.The 1-,2-and 3-years Recurrence-free survival(RFS)rate were 69.4%,63.9%,63.9% in the group A respectively,76.7%,66.7%,66.7% in the group B respectively,and 75.7%,68.6%,65.7% in the group C respectively.Compared with group A,group B or group C showed significantly improved 1-year OS(P=0.044,P=0.017),In addition,there was no significant difference between RFS and OS at any end point when compared between groups and groups.Cox regression analysis showed that tumor size and microvascular tumor thrombus were independent risk factors for postoperative recurrence as well as prognosis.ConclusionFor patients with HCC who underwent radical resection,postoperative adjuvant TAE or TACE therapy can improve overall 1-year survival without improving recurrence-free survival and long-term overall survival;There was no difference in the efficacy of adjuvant TAE and TACE after radical resection.