Phlegm Resolve Depression Party Treat Insomnia (Phlegm Heat Interference) On Clinical Research

Objective:Evaluation of phlegm resolve depression party on the treatment of phlegm heat disturbance type insomnia clinical efficacy and safety.Methods:Adopt the method of randomized, controlled clinical trials. A total of 65 patients with selected into standard, randomly divided into two groups,32 cases of treatment group and control group 33 cases. Experimental group oral phlegm resolve depression,1 bag each time,3 times a day. Control group to estazolam tablets (1 mg/piece, jiangsu changzhou pharmaceutical production, H32020699) approved by the state,1 piece/time, half an hour before sleep every night. Three consecutive period of treatment is one period of treatment (1 week). Before treatment, treatment, 1 week,2 weeks and 3 weeks respectively with Pittsburgh sleep quality index (PSQI) score and TCM syndrome scale score, respectively before and after the total course of treatment for general inspection project (blood pressure, heart rate and breathing), observe patients during treatment of adverse reactions, clinical effectiveness and safety evaluation of eliminating phlegm to resolve depression.Results:Pittsburgh sleep quality index (PSQI) score [1-3] comparison:week 1 control group after treatment in patients with sleep improved (P< 0.05) than experimental group; Week 2 and 3 weeks of two groups of patients with sleep improved equivalent (P> 0.05); Syndromes scale score comparison:experimental group and control group after 3 course of the treatment before the treatment are improving, the experimental group (P= 0.00) to improve the situation is better than that of control group (P= 0.04), the comparison between the two groups (P< 0.01) there were significant differences, examination in patients with syndrome of traditional Chinese medicine to improve the situation is better than control group; (3) the clinical curative effect comparison:sleep the two groups after treatment than before improvement in experimental group (the total effective rate was 90.0%) clinical efficacy is equivalent to the control group (the total effective rate was 93.3%). Upon examination, P= 0.09, two groups of patients with sleep improve there was no statistically significant difference; (4) syndromes curative effect comparison:two groups of patients also had an improved earlier syndromes, upon examination, P< 0.01, the difference was statistically significant, experimental group (the total effective rate was 93.3%) improve the syndromes is better than that of control group (the total effective rate was 56.7%); Adverse reactions (5):after the total course of treatment, control group patients the incidence of adverse reactions (16.7%) than group (6.7%).Conclusion:Phlegm resolve depression can significantly improve phlegm heat on one type of insomnia patients sleep quality and syndromes, less adverse reaction, curative effect is remarkable.