| Objetivce: The study adopted the method of interview research to survey HIV/AIDS patients and HIV/TB patients in Guigang city with questionnaire,in order to compare the HARRT medication adherence of two groups,and analyze that if combined with TB infection have a direct impact on medication adherence.Analyze the influencing factors on medication adherence.Provide effective suggestions to improve the medication adherence of patients in Guigang city.Methods: The research was a cross-sectional survey,retrospective and field investigation were used.Guigang city people's hospital was the field sit,select random sampling as the sampling method,choose 100 HIV/AIDS patients and 50 HIV/TB patients as the object of study.Questionnaire survey was carried out on the patients,collceting basic information and case information.The contents included gender,age,marriage,cultural,treatment plan,disease staging,viral load,CD4+T cell count,medication adherence,medication beliefs,medication barriers,social support,self-efficacy and so on.The software Epidata and SPSS were used to perform the analysis.Analyze by statistical ratio,rate,Chi-square test,Student's t test,and logistic regression.Compare the HARRT treatment adherence of two groups,and analyze the influencing factors on medication adherence.Results: 1.Compared with general characteristics of two groups,the following items had significant statistical differences(P < 0.05),such as cultural(P=0.01),occupation(P=0.002),medical insurance(P=0.005),salary(P=0.010),whether to understand(remember)medication education(P=0.005),treatment plan(P=0.042).2.The HARRT medication compliance rate of HIV patients was 66%,rate of HIV/TB patients was 68%,there was no significant statistical difference(P=0.806>0.05)between two group.3.The logistic regression analysis showed that whether to understand(remember)medication education(OR=2.479,95%CI 1.024~6.004,P=0.044)and whether to take medication reminder(OR=3.149,95%CI 1.277~7.766,P=0.013)were protective factors of medication adherence to HIV patients(P<0.05).Higher score of medication beliefs(OR=1.559,95%CI 1.009~2.410,P=0.046)and self-efficacy(OR=1.069,95%CI 1.015~1.125,P=0.011)were protective factors of medication adherence to HIV/TB patients(P < 0.05).Hazard factors were higher score of medication barriers(OR=0.927,95%CI0.873~0.983,P=0.012),longer time of treatment period(OR=0.040,95%CI0.003~0.492,P=0.012),higher level of viral load(OR=0.029,95%CI0.001~0.581,P=0.021),(P=<0.05).Conclusion: There was no significant statistical difference(x2=0.060,P=0.806>0.05)between HIV/AIDS patients and HIV/TB patients in medication adherence,both two groups were in a low level.Thus,we didn't yet prove that combined with TB infection had a direct impact on the medication adherence of HARRT treatment in HIV/AIDS patients.The influence factors were varied in the two groups,effective suggestion should be given to different patients to improve the adherence,and they can learn from each other.HIV/AIDS patients should strengthen medical education and medication reminder.HIV/TB patients should strengthen medication beliefs and self-efficacy,reduce medication barriers.Strict supervision and administration should be taken to the people who has long treatment period.Patients with high viral load needed to find the reasons carefully,adjusted the treatment when necessary. |
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