The Research On The Effect Of Exercises Combined With Equol On Breast Cancer Tissue In DMBA Induced Wistar Rat Breast Cancer Model

Objective:The aim of the research is to study the effect of exercises combined with equol on breast cancer tissue in DMBA Induced Wistar Rat Breast Cancer Model and discuss the mechanism.Methods:For the construction of induced mammary gland,Six-week-old female Wistar rat were received gavage on a dosage of 10mg/ml DMBA for eight weeks.After successful modeling,the rat were randomized into four groups:The control group(group C),the females of phenol group(group E),exercise group(P group),motion plus females phenol group group(PE).Among them,C and P group normal feeding water daily.E and PE group per 200 mg daily females of phenol in sesame oil into 1000 g solution,which is 200 mg dose females of phenol in rats of females of phenol by gastric lavage.Set the movement of P and PE group to swim,sink depth of 50 cm,water temperature 30℃ or so,exercise every day 30 min 5 min rest,a day four groups,sports eight weeks.Results:compared with group C,other groups were very significant differences(P<0.01),Bax protein expression levels,Caspase-3 increased significantly;The NF-kappa B p65 expression.Compared with P group,group C and PE group had very significant difference(P<0.01),and E group there was no significant difference(P>0.05).Compared with PE group,other groups were very significant differences(P<0.01),PE group than other groups of Bax protein expression levels,Caspase-3 increased significantly;The NF-kappa B p65 express declined significantly.Prompt aerobic exercise combined with females of phenol can cause DMBA breast tissue cell apoptosis in rat model of breast cancer,reduce inflammation of the body.Conclusion:long-term the intensity of movement joint females phenol can inhibit DMBA induced the growth of breast cancer in rats.Improve Bax protein in breast cancer tissue,Caspase-3 protein,regulating the activity of NF-kB P65,promote cell apoptosis may be movement joint females of phenol on induced rat breast cancer growth of one of the important physiological mechanism.