Clinical Quadruple Viable Agents To The Intestinal Barrier Dysfunction In Critically Ill Patients

Objective:To explore critically ill patients embodiment containing Bifidobacterium,Streptococcus thermophilus,Lactobacillus bulgaricus,Lactobacillus acidophilus bacteria preparation EN quadruple therapy to improve intestinal barrier function in patients and reduce the impact of morbidity and efficacy.Methods: critically ill patients Xinjiang Uygur Autonomous Region People’s Hospital intensive care unit from May 2014 to June2015 were treated intestinal barrier dysfunction in 102 patients,according to the random number table were randomly divided into observation group and control group.Two groups of patients were given basic treatment plus nutritional therapy.In terms of nutrition therapy,the control group received conventional nutritional therapy,nutrition experimental group received routine treatment plus four companies viable preparations,800 ml / d.After the two groups were observed before treatment and 7,14 d peripheral diamine oxidase(DAO),plasma D-lactic acid,changes in serum endotoxin;changes in nutritional parameters during treatment;the incidence of complications;infection rates;dung / pole distribution ratio;the incidence of gastrointestinal motility disorders;hospitalization costs;nutrition therapy costs.Results:Compared with the control group without the test ALB significant difference(P>0.05);Intervention 7d,14 d groups PA levels began to recover,the recovery of the experimental group compared with the control group,and the difference between the two groups was statistically significant(P <0.05);two groups of patients the first 14 d,14d after the test treatment group reduced intestinal mucosal barrier function of the three indicators of magnitude greater than the control group,the difference was statistically significant(P<0.01);experimental and control groups feces ball / stem ratio test group of bacteria ≥40% in 11 patients(21.6%),bacteria≥40% in the control group 20 patients(39.2%),the difference between the two groups was statistically significant(P<0.05);experimental group gastrointestinal motility disorders were lower than the control group,the difference between the two groups was statistically significant(P<0.05);experimental group lung infections,urinary tract infections,and the overall infection rate was significantly lower than the control group,two groups there was significant difference between(P<0.05);experimental group,the total number of days of hospitalization,EN time required to reach the target supply amount,duration of infection was significantly less than the control group,the difference was statistically significant(P <0.05);experimental group were lower than the control group,total hospital costs,the difference between the two groups was statistically significant(P<0.05).Conclusion:four with viable preparations can improve intestinal permeability in critically ill patients,while improving the intestinal microflora balance,repair intestinal mucosal barrier function,helps the colonization of beneficial bacteria in the intestines,reduce infection in critically ill patients and concurrency the occurrence of disease,thereby improving patient outcomes,improve the clinical efficacy,clinical application should be promoted.