Study On The Expression Of Serum MiR-208a In The Early Stage Of Acute Myocardial Infarction And Before And After Interventional Therapy

Objective:To investigate the expression changes of serum microRNA-208 a in patients with acute myocardial infarction(myocardial infarction acute, AMI) in early stage and emergency percutaneous coronary intervention(coronary intervention percutaneous, PCI) before and after treatment.Methods: 30 cases of AMI patients admitted to hospital with acute chest pain, 20 cases of healthy physical examination, AMI group at admission and admission 12h(6 hours after the end of) collection of blood, healthy control group in the early morning fasting blood, using real-time fluorescence quantitative polymerase chain reaction(real-time reaction chain polymerase qRT-PCR) and I troponin microRNA-208a(I), creatine kinase isoenzyme(kinase isoenzyme CK-MB) AMI expression levels of mi R-208 a and cTnI, CK-MB expression changes before and after PCI treatment miR-208 a AMI.Results: the level of serum mi R-208 a in AMI patients was significantly higher than that in healthy control group(P<0.05), the levels of serum miR-208 a were positively correlated with cTnI and CK-MB(r1=0.356, P1=0.045; r2=0.456, P2=0.011). The serum miR-208 a levels were significantly decreased in AMI patients after PCI treatment(P<0.05).Conclusion: the expression of serum miR-208 a in AMI patients is significantly increased, which may be a potential biomarker for early diagnosis of AMI.