Comparative Analysis Of The Effect Of Calcium Dobesilate On The Detection Of Serum Creatinine And Renal Function: A Clinical Study

Objective Observe the effect of Calcium Dobesilate on the detection of serum creatinine, and evaluate the therapeutic effect of Calcium Dobesilate to patients with Chronic kidney disease(CKD).Method Totally 108 Chronic kidney disease patients were according to the condition of renal function divided into treatment group(n=60) and control group(n=48). For control group, conventional treatment was applied to the subjects, included I Coated Aldehyde Oxystarch Capsules 5g tid take orally;II,low salt, low fat low phosphorus low protein diet(protein intake < 0.6g/kg/d and Na Cl intake < 6g);III, control of blood pressure(BP < 130/90 mm Hg), glucose(Glu < 7.9mmol/L), regulating electrolyte; for treatment group, Calcium Dobesilate 500 mg per os TID was applied to the subjects beside conventional treatment. Sarcosine oxidase method, Jaffe’s method and glomerular filtration rate was applied for 4 weeks during the treatment. 108 patients’ kidney function was observed,detection of 38 cases of stage III and IV CKD patients before and after treatment,.Result I Calcium dobesilate can improve patients with e GFR levels, treatment group in patients with EGFR showed an increasing trend(before and after Sarcosine oxidase method and Jaffe’s method group respectively(35.79 + 16.53),(43.31 + 15.25) M1 /(min- 1.73m2), t=4.912, P < 0.05;(35.47 + 14.42),(37.13 + 16.33) M1 /(min-1.73m2), t=1.435, P < 0.05.II In the treatment group, Sarcosine oxidase method and Jaffe’s method group serum creatinine decreased [(before and after Sarcosine oxidase method treatment group respectively(304.80 + 201.08), 235.44 + 131.33 ml / L, t=2.764, P < 0.05; Jaffe’s method group(267.85 + 109.65), 227.85 + 97.69 ml / L, respectively. T=1.892, P < 0.05), compared with the control group, there was significant difference(t=4.539, P < 0.05). T=2.323, P < 0.05), and enzymatic group significantly decreased(P < 0.01).III Lower before and after the treatment respectively(480.34 + 129.24), 425.74 + 117.56 ml / L treatment group, the level of blood uric acid, t=3.325, P < 0.05]; treatment of blood urea nitrogen(BUN) no obvious change, and there is no significant difference between the treatment group and the control group(P > 0.05). IV 38 patients after the treatment of GFR was performed in the treatment group, III 13, IV 9, the control group III 11, IV 5. Calcium dobesilate on GFR no effect(before and after treatment in treatment group respectively(35.30 + 16.74),(35.69 + 1.684) ml / min, t=1.983(P > 0.05); in the control group, respectively(34.45 + 15.67),(36.89 + 15.75) ml / min, t=2.017, P > 0.05), compared with the control group, no significant difference(t=5.324,P > 0.05).Conclusion I In the short term, calcium dobesilate has no obvious improvement on GFR. The protective effect of calcium dobesilate on renal circulation needs further study;II calcium dobesilate have negative obvious influence on detection of sarcosine enzymatic creatinine in clinical operation should pay attention to taking the detection method of patients with calcium dobesilate renal function, to avoid covering disease.