Gender Differences In The Prevention Of PONV With Laparoscopic Operation

Part1 Gender differences on smoking patients in the incidence rate of postoperative nausea and vomiting with laparoscopic operationObjective:Discuss gender differences on smoking patients in the incidence rate of postoperative nausea and vomiting with laparoscopic operation.Methods:Selection in May 2014 to May 2015, ASA Ⅰ-Ⅱ level, aged 18 to 60, fitting line of 246 cases of laparoscopic surgery patients in Tianjin Medical University General Hospital, but the final effective 240 cases, male 120, female 120 cases. 240 patients were randomly divided into four groups(n=60 each): the male smoking group(MS), the male non smoking group(MN),the female smoking group(FS),the female non smoking group(FN). Records of patients of postoperative nausea and vomiting in 24 hours, the degree of nausea and vomiting, the first nausea time,the first vomiting time and cases patients needing treatment resistance of nausea and vomiting. Statistics the incidence of PONV, the degree of PONV score, the first nausea time and the first vomiting time, sex differences in analysis of smoking on the prevention of PONV.Results:MS group within 24 h after surgery none of PONV in patients were obviously redundant MN group(P < 0.05), the total incidence of PONV MS group was obviously lower MN group(P < 0.05), the MS group of PONV Ⅳ level and use of nausea and vomiting cases drug intervention obviously less than the MN group(P < 0.05);MS group of the first nausea time and the first vomiting time was significantly longer than MN group. FS with FN group compared with patients without PONV cases, total incidence of PONV,the first nausea time, the first vomiting time and PONV Ⅳ level and use of nausea and vomiting drug intervention in cases of no statistical difference(P > 0.05).Conclusion: Smoking can obviously reduce the incidence of PONV male patients and delay postoperative nausea and vomiting time of male patients, but smoking can not reduce the incidence of PONV female patients and delay postoperative nausea and vomiting time of female patients.Part2 Static dexamethasone, static tropisetron on postoperative nausea and vomiting(PONV) in prevention of gender differences with laparoscopic operationObjective:Discuss static dexamethasone, static tropisetron on postoperative nausea and vomiting(PONV) in prevention of gender differences with laparoscopic operation.Methods:Selection in December 2014 to December 2015, ASA Ⅰ-Ⅱ level, aged 18 to 60, fitting line of 382 cases of laparoscopic surgery patients in Tianjin Medical University General Hospital, but the final effective 360 cases, male 180, female 180 cases. 360 patients were randomly divided into six groups(n=60 each): the male dexamethasone group(MD), the male tropisetron group(MT), the male control group(MC), the female dexamethasone group(FD), the female tropisetron group(FT), the female control group(MC).MD,FD group immediately prior to the anesthesia induction intravenous drip dexamethasone 0.15 mg/kg. MT,FT group immediately prior to the anesthesia induction intravenous drip tropisetron 5mg. MC, FC group static note amount of normal saline. Records of patients of postoperative nausea and vomiting in 24 hours, the degree of nausea and vomiting, the first nausea time,the first vomiting time and cases patients needing treatment resistance of nausea and vomiting. Statistics the incidence of PONV, the degree of PONV score, the first nausea time and the first vomiting time, sex differences in analysis of dexamethasone and tropisetron on the prevention of PONV.Results:1.MD within 24 h after surgery group none of PONV in patients were obviously redundant MC group(P < 0.05), the total incidence of PONV MD group was obviously lower MC group(P < 0.05), the MD group of PONV Ⅳ level and use of nausea and vomiting cases drug intervention obviously less than the MC group(P < 0.05); MD group of the first nausea time and the first vomiting time was significantly longer than MC group. FD with FC group compared with patients without PONV cases, total incidence of PONV, the first nausea time, the first vomiting time and PONV Ⅳ level and use of nausea and vomiting drug intervention in cases of no statistical difference(P > 0.05).2. MT within 24 h after surgery group none of PONV in patients were obviously redundant MC group(P < 0.05), the total incidence of PONV MT group was obviously lower MC group(P < 0.05), the MT group of PONV Ⅳ level and use of nausea and vomiting cases drug intervention obviously less than the MC group(P < 0.05);MT group of the first nausea time and the first vomiting time was significantly longer than MC group. FT within 24 h after surgery none of PONV in patients were obviously redundant FC group(P < 0.05), the total incidence of PONV FT group was obviously lower FC group(P < 0.05), the FT group of PONV Ⅳ level and use of nausea and vomiting cases drug intervention obviously less than the FC group(P < 0.05); FT group of the first nausea time and the first vomiting time was significantly longer than FC group.Conclusion: 1.Static dexamethasone injection before induction of general anesthesia on postoperative nausea and vomiting(PONV) prevention of gender differences, can obviously reduce the incidence of PONV male patients, and delay postoperative nausea and vomiting time of male patients. Static dexamethasone can not reduce the incidence of PONV female patients and delay postoperative nausea and vomiting time of female patients.2.Static tropisetron injection on postoperative nausea and vomiting(PONV) prevention, can obviously reduce the incidence of PONV,for male and female patients, and delay postoperative nausea and vomiting time of male and female patients,especially for female better.