The Study On The Correlation Between The Risk Factors Of Carotid Atherosclerosis And Plaque Composition

Objective The use of 3.0T high resolution MRI imaging technology, component analysis of carotid atherosclerotic plaque, plaque stability, and to explore the relationship between carotid atherosclerosis and traditional risk factors.Method Selected from September 2013 to 2014 during September because of acute ischemic cerebral vascular disease in Clinical College of Tianjin Medical University; the fourth central hospital patients 105, which 65 males, 40 females, age, 41-85 years old in average 63±9.07 years old. Patients with agitation, suffering from claustrophobia, in vivo pacemaker, hidden automatic defibrillators, coronary memory in the scaffold, cerebral aneurysms after clipping and cardiac valve replacement patients due to magnetic resonance imaging(MRI) is taboo, are not included in this study. Using Philips intera Achieva 3.0T MRI scanner, with eight channel neck phased array surface coil and ECG gated, on patients with bilateral carotid artery were scanned with 3DTOF bright blood, black science technology and T1 WI, T2 WI sequence of scan results were analyzed determination of carotid plaque stability and composition. Check the blood pressure data acquisition after the onset of blood glucose, blood lipid and other laboratory records, risk in patients with previous history of hypertension and diabetes, smoking history and other factors. Using SPSS 19 statistical software, according to the characteristics of data, measurement data with standard deviation; count data expressed by rate. The application of correlation between two yuan Logistic regression analysis component comparison of patients’ age and sex, blood pressure, blood lipids, diabetes, smoking, body mass index and other traditional risk factors and the stability of plaque and plaque. P<0.05 was statistically significant.Results 105 patients with high resolution MRI examination were found to meet the study criteria of carotid atherosclerotic plaque 206, including unstable plaque 92, stable plaque 104. Plaques with central necrosis of the lipid in 92 cases(45%), with a thin fibrous cap or rupture in 9 cases(4%), intraplaque hemorrhage 9 cases(4%), appeared in plaque calcification in 51 cases(25%). Hypertension, diabetes, gender and atherosclerotic plaque stability, the OR values were 2.065(95%CI:1.010-4.220), 1.908(95%CI:1.004-3.625),2.886(95%CI:1.339-6.221).Hypertension,diabetes, gender and plaque necrosis related lipid core, OR values were 2.065(95%CI:1.010-4.220), 1.908(95%CI:1.004-3.625), 2.886(95%CI:1.339-6.221). Age,gender and intraplaque hemorrhage,OR values were 1.142(95%CI:1.016-1.285), 9.371(95%CI:1.033-85.49). Age and TC and plaque calcification, OR values were 1.085(95%CI:1.035-1.138), 2.318(95%CI:1.279-4.203). HDL-C and plaque rupture or thin fibrous cap had a negative correlation, OR = 0.134(95%CI:0.000-3.484).Conclusion 1.3.0T high resolution MR can qualitatively analyze the components of carotid atherosclerotic plaque and determine the stability of the plaque, which provides a new scientific basis for the prevention and treatment of acute cerebrovascular disease. 2.The level of HDL in patients with acute ischemic cerebrovascular disease is negatively correlated with the occurrence of thin or broken fiber cap. The fiber cap has certain protective effect, which can maintain the stability of the atherosclerotic plaque. 3.The age of patients with acute ischemic cerebrovascular disease and TC were positively correlated with the calcification of plaque. 4.The acute ischemic cerebrovascular disease in patients with older age, male sex, hypertension, diabetes crowd of carotid artery plaque tends to be more unstable, the male sex, hypertension, diabetes is independent risk factors of unstable plaque, caused the early attention helps to delay the disease progression and recurrence.