Association Analysis Between Rs13155212 And CAD In A Chinese Population

In the 21 th century, people’s physical condition is very rich, more and more " illness of affluence " became a human health problem. Coronary artery disease(CAD) is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden coronary death. It is a member of cardiovascular diseases. For nearly 10 years, the scientist on C AD has been focused onto the genetic mechanisms. Genome-wide association studies(GWAS) on CAD has made a huge breakthrough with more than 20 articles published, and a lot of loci significantly associated with CAD has been found. Currently CAD susceptibility loci have been found in the Americas or Europe. In order to verify whether these sites can be repeated in the C hinese population, also hope to find a new site in Chinese population, many research institutions has done a series of work. This article is intended to verify the SNP rs13155212 which located on the gene AGGF1 whether it is significantly associated with coronary artery disease. We conducted a case-control association analysis using 3066-2422 samples. Eventually found in Chinese population, rs13155212 was no significant association with CAD(P=0.365,OR=1.053). After the adjustment of covariates, it still has no significant association(P=0.395,OR=1.054).This study has verified the SNP-- rs13155212 whether it is significantly associated with CAD using a larger sample size in Chinese population. It has no significant association with CAD. So in the future studies will verify another SNP in Chinese population.