| Objective: To assess the curative effect of combined cognitive rehabilitation training on cognitive dysfunction in amphetamine-type stimulant(ATS) dependent patients, and to give a theoretic support for exploring new technique of clinical treatment.Method: The current study use parallel controlled design and blind method. 60 Subjects in compulsory isolation detoxification institute were randomly assigned into two groups, each group had 30 subjects. The control group was only treated with regular education, such as drug and legal knowledge, entertainment activities. In addition to regular education intervention group, also received 24 weeks combined cognitive rehabilitation training. Combined Cognitive Rehabilitation Training was the major intervention which contained group cognitive rehabilitation training, drug rehabilitation exercise including cognitive related acupoint massage and aerobics rehabilitation exercise, balance training. All subjects’ cognitive function assessed at baseline and after 24 weeks. Use Chinese version of Cog State Battery to assess the subjects’ cognitive function. Detected 8 aspects of cognitive funtion: processing speed、attention and vigilance、verbal learning and memory、visual learning and memory、working memory 、Problem-solving and error monitoring 、socio-cognitive、spatial working memory. SPSS 17.0 was used to analyze data. 2 test was used for the categorical variables. Independent t test was used for the continuous variables. 2(group score: Intervention / Control) ×2(Time: Intervention/Control) repeated measures analysis of variance was used for test scores of 8 dimensionality with total score of Cog State test at baseline as the covariate variable. Reductive ratio in 8 dimensionalities were used for the independent t test between two groups.Result: 60 subjects included this study, 56 of 60 complete baseline and follow-up research. All subjects of intervention group finished the whole study while control group had 4 subjects quitted before baseline. The average age of all subjects was 34.4, mainly of them were male(64.3%), not married(67.9%). There were not statistical significant difference between intervention group and control group(p<0.05). Intervention group had a higher scores than control group on visual learning and memory[FOCL(1,54) = 7.27, p = 0.010]、working memory[FTWOB(1,54) = 6.63, p = 0.013]and had less mistakes on spatial working memory[FCPAL(1,54) = 6.183, p = 0.017];and no statistically significant difference in processing speed、attention and vigilance、verbal learning and memory、Problem-solving and error monitoring 、socio-cognitive. Intervention group also had a better average reductive ratio than control group on visual learning and memory subscale(0.06±0.12 vs-0.03±0.14)、working memory subscale(0.12±0.15 vs 0.01±0.19) and spatial working memory subscale(-0.46±0.35 vs-0.15±0.49). There was no statistically significant difference in balance function tests at baseline. Repeated measures analysis of variance was used for comparing intervention and control groups’ balance function with three distance balance beam. Balance function better in intervention group than control group(F20m=25.22,p<0.001;F32m=28.60,p<0.001;F40m=23.10,p<0.001). Further comparative reduction rate of two groups, the result consistent with the above,[20m(-16.76 ± 9.26 vs 0.47 ± 9.48; p<0.001)、32m(-14.28±8.96 vs 5.12±11.12; p<0.001)and 40m(-13.03±8.99 vs 1.63±7.80; p<0.001)]. Average number of disciplinary in intervention group during the 24-week study was significantly less than the control group(p <0.001). Impulsive behavior of the intervention group was also significantly less than the control group(p = 0.012).Conclusion: Combined Cognitive Rehabilitation Training can improve cognitive function in Amphetamine-type stimulant dependent patients. |
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