The Correlation Study Between CRP And Acute Traumatic Coagulopathy And Prognostic

Objective To investigate the relationship between the admission serum C-reactive protein level and the prognosis of the severe multiple trauma patients with acute traumatic coagulopathy.Methods Collected 215 multiple trauma patients, what the Shanghai sixth people’s hospital emergency department rescue room admitted and transferred to EICU from January 2014 to December 2014. According to international normalized ratio≥1.3 and activated partial thromboplastin time≥35seconds, or platelet count≤100x 109/L within 24 hours after trauma, divided the patients into ATC group of65 cases with no ATC group 150 cases,to compare the admission serum C-reactive protein level of two groups, and compare the relationship between ATC and the ad-mission infection and mortality rate. To compare the relationship between the admi-ssion serum C-reactive protein level and the admission infection and mortality rate.Multiple regression analysis the correlation between the admission serum C-reactive protein level and ATC and its prognosis.Results The admission serum C-reactive protein level of ATC group was si-gnificantly higher than the non-ATC group, the concurrent infection rate and mo-rtality of ATC group was higher than that in Non-ATC group(60% vs. 18.7%,P<0.001 and 12.3% vs. 2.7%, P=0.008). The admission serum C-reactive protein level of infection、death group was higher than that in non-infection、survival gr-oup. Multiple logistic regression analysis found that the admission serum C-react-ive protein level was correlated with occurrence of acute traumatic coagulopathy[OR=1.012,95% CI(1.007, 1.016),P<0.001], was correlated with infection rate and mortality of acute traumatic coagulopathy [OR=1.011,95% CI(1.001,1.015),P=0.045 and OR=1.012,95% CI(1.000, 1.025),P=0.047].Conclusion The admission serum C-reactive protein level 、 infection rate and mortality of severe multiple trauma patients with ATC was significantly higher than the non-ATC group. The admission serum C-reactive protein level is associated with infection and death after admission in ATC patients. Multiple regression analysis found that high admission serum C-reactive protein level is the influence f actors of ATC、infection and death.