Objectives Using TCM inheritance system platform, analysis and mining of Professor Liu Yujie in treating depression dialectical thinking and medication experience, provide theoretical guidance and experience for the treatment of depression.Methods The collection of Professor Liu Yujie clinical treatment of depression in the medical record, input "traditional Chinese Medicine Inheritance assist system(V2.5)".Using the software integration rule analysis, improved mutual information method,complex system entropy clustering, unsupervised entropy and hierarchical clustering data mining methods, analysis the frequency of use of the drugs in the prescription and the interrelated rules, Professor Liu Yujie in the treatment of depression medication experience of mining.Results 1 A total of 122 prescriptions were analyzed, and a total of 106 Chinese herbal medicines were produced. The frequency analysis, which higher application frequency of drug are: poria, radix salviae miltiorrhizae, radix curcumae, rhizoma pinelliae, raw oysters,keel, albizzia julibrissin, polygala root, tuckahoe, rhizoma acori tatarinowii, licorice, dried tangerine peel, bamboo shavings, zhishi.2 Through the analysis of the prescription law, used a combination of drugs and commonly used drugs on. : pinellia, poria; curcuma root, poria cocos; salvia miltiorrhiza,tuckahoe; radix curcumae, radix salviae miltiorrhizae; salvia miltiorrhiza, albizzia julibrissin; radix curcumae, radix salviae miltiorrhizae, albizzia julibrissin; keel, oysters,acorus gramineus, polygala root, poria with hostwood, used a combination of drugs.3 Take drug correlation coefficient above 0.03 commonly used drugs of 52,polygalaceae, raw malt; amomum villosum, ginger; albizzia bark, rhizoma atractylodis;amomum fruit, rhizome atractylodis; amomum fruit, poria; pinellia, dried orange peel;poria with hostwood, malt, albizzia julibrissin, ginger and so on.4 The new analysis module that core of drug combinations of 91, tribulus terrestris,safflower; gastrodia elata, zhejiang fritillaria; evodia rutaecarpa, red ochre; bulbus fritillariae thunbergii, sandalwood; bulbus fritillariae thunbergii, trichosanthes; bulbus fritillariae thunbergii, tribulus terrestris; mulberry, aspartame and other.5 Drug combination of core 14, including platycodon grandiflorum, orange leaves,forsythia; loquat leaf, almond, motherwort; cicada, longchi, tribulus terrestris, are derived.6 That new candidate prescription 7, such as loquat leaf, almond, motherwort, mte zhi;cicada, longchi, tribulus terrestris, concha mauritiae, turmeric and other.Conclusions Professor Liu Yujie in the treatment of depression to make good use of the ancient prescription, and prescription of traditional Chinese medicine, take its essence,adopt many long, fleible application, not to stick to one pattern. On the basis of syndrome differentiation, often multi compound and used to enhance and consolidate the effect.Make the best use of drugs, drug "and" as the guiding principle, emphasize the combination of dynamic and static state, Lifting and using, with the use of hot and cold medicine, with the use of laxatives and clear tonic, and so on. According to the physiological characteristics and pathological changes of the viscera, the compatible application. The use of sedative sadashi drugs, drugs and drug use of wind assistance. |