Effect Of Sulfentanil Combined With Dexmedetomidine On Postoperative Analgesia In Elderly Patients Undergoing Video-assisted Thoracic Surgery

【Objective】To study effect of sulfentanil combined with dexmedetomidine on postoperative analgesia in patients undergoing video-assisted thoracic operation.【Methods】Ninety senile patients undergoing thoracoscopic surgery were randomly divided into three groups: group C1 received sulfentanil 1.5μg/kg and tropisetron 5mg;group C2:sulfentanil 2μg/kg and tropisetron 5mg;group E:Sulfentanil 1.5μg/kg+dexmedetomidine2μg/kg+tropisetron 5mg.Visual analog scale(VAS) and Ramsay scores were recorded after extubation for 4, 8, 12, 24 and 48 hours. The number of self-controlled press of the pump at1-4h、4-8h、8-12h、12-24 h after extubation and the incidence of side effects were recorded.【Results】VAS scores of group C1 were significantly higher than that of group C2 and E at 4h, 8h,12 h, 24 h and 48 h after extubation(P < 0.05).Ramsay scores group C1 were significantly lower than that of group C2 and E at 4h, 8h, 12 h, 24 h and 48 h after extubation(P < 0.05).There was no statistically significant difference between group C2 and group E in VAS scores and Ramsay scores. The number of self-controlled press of the pump in group C1 was markedly more than that of group C2 and E at 1-4h 、 4-8h、 8-12 h 、12-24 h after extubation(P < 0.05).The incidence of nausea,vomiting and pruritus in group C2 was higher than that of group C1 and E(P < 0.05),There was no significant difference between group C1 and group E. The C1 group pethidine dosage was significantly higher than that of group C2 and E(P < 0.05), there was no significant difference between group C2 and E.【Conlusion】Dexmedetomidine can reduce postoperative consumption of sulfentanil in elderly patients undergoing video-assisted thoracic surgery, and decrease the incidence of postoperative adverse reactions.