The Study Of Sleep Disorder Factors In Patients With Guillain-barre Syndrome

Objective: The purpose of this paper is to evaluate the relationships of sleep quality of patients with Guillain-Barre syndrome(GBS) with cerebrospinal fluid hypocretin- 1(HCRT-1)and analyze the contributing factors,thus appropriate intervention as soon as possible, to promote patients recover at an early date.Methods and Result: Methods: Totally 38 patients with GBS in the Affiliated Hospital of He Bei University were enrolled in the study. Pittsburgh Sleep Quality Index(PSQI) and Richards-Campbell Sleep Questionnaire(RCSQ) were used to evaluate their sleep quality.According to the score of the questionnaires, we divided the patients into two groups:sleep-disorder group and non sleep-disorder group, and then detected the cerebrospinal fluid HCRT-1 level in the two groups by using ELISA method. To evaluate the numbness and pain degree of patients by Wong and Baker Face Scale(WBFS);to evaluate the severity of the GBS by GBS Disability Scale(GBS DS);to evaluate the patients with anxiety and depression by Hospital anxiety depression rating scale(Hopital anxiety and depression scale HADS).Results:RCSQ-14 consecutive days of 38 patients for score showed that the highest score at 4 days before admission and the sleep gradually improved after 1 week,17 patients had poor sleep during hospitalization.The RCSQ score of 38 patients was 59.58±3.26, and highly sleep-abnormal rate was 45%.PSQI-24 cases had basic sleep disorder.The PSQI score was 9.75±0.82, and sleep-disorder rate was 65%. The cerebrospinal fluid HCRT-1 level in the sleep-disorder group was significantly lower than that in the non sleep-disorder group.Analysis showed that anxiety,pain,numbness and severe dyskinesia should be associated with sleep disorders in patients.Conclusions: Nearly 50% of patients with GBS had sleep disorders. Besides, cerebrospinal fluid hypocretin- 1 levels decline can be affected by GBS patients with sleep disorders.In addition,anxiety, pain, numbness and severe dyskinesia should be associated with sleep disorders in patients.