The Clinical Analysis Of Some Biochemical Indicators In Patients With Preeclampsia

Objective:The purpose of this study is to discuss the clinical significance of changes in routine blood, Liver and kidney function and to discuss how UA and Cys-C to influent the pregnancy outcomes, through to retrospectively analysis routine blood, Liver and kidney function of 202 patients with Preeclampsia.Methods:From July 2014 to August 2015,202 patients with Preeclampsia in Yan、an University Affiliated Hospital obstetrics were selected as research group, including 101 mild Preeclampsia women and 101 severe Preeclampsia women, while randomly selected 95 normal pregnant women in the same period as a control group. Two groups of cases are single live births, gestational age≥34 weeks,rule out underlying medical history, congenital vaginal malformations, history of recurrent spontaneous abortion and stillbirth. The diagnosis standard of Preeclampsia is based on the eighth edition of " Obstetrics and Gynecology",which chief edits by Xie Xing.Collect the general information of two groups, collect the number of WBC, RBC, HCT, HB, PLT; PT, Fb; ALT, AST, GGT; Ur, Cr, UA, Cys-C. Collect the arised cases of placental abruption,postpartum hemorrhage,preterm birth, low birth weight newborn, fetal distress, asphyxia of newborn and stillbirth.All the data were analyzed by SPSS 21.0. measurement data with mean±standard(x±S) deviation, use ANOVA analyzed in more groups, use LSD-L analyzed in two groups; count data use chi-square test, use α=0.05 as the testing standard, P<0.05 for statistical significance.Result:1.The comparison of general data between the research group and control group:Compared two groups of pregnant women in age and gestational age, there were no statistically significant difference(P > 0.05).2.The comparison of the research group and control group in routine blood indicators:Three groups of pregnant women in the WBC, RBC, HCT number changes were not obvious, and there was no statistically significant difference(P > 0.05). At PLT number, sever Preeclampsia was more lower than mild Preeclampsia and control group, there were statistically significant differences(P < 0.05),while the number of PLT between mild Preeclampsia and control group have no obvious changes, there was no statistically significant differences(P >0.05).3.The comparison of the research group and control group in blood coagulation function indicator:The PT number of severe compared to the mild Preeclampsia and the control group, differences were all statistically significant(P < 0.05),in which the PT number of severe Preeclampsia was more shorter than mild Preeclampsia and control group, the changes between mild Preeclampsia and control group was not obvious and it was no statistically significant difference(P > 0.05). Three groups of pregnant women in the Fb number changes are not obvious, and there was no statistically significant difference(P > 0.05).4.The comparison of the research group and control group in liver function indicator:Three groups of pregnant women in the ALT, AST, GGT number changes are not obvious, and there was no statistically significant difference statistically significant differences.5.The comparison of renal function indicator between research group and control group:The numbers of UA and Cys – C in severe Preeclampsia was more higher than mild Preeclampsia and control group, differences were all statistically significant(P < 0.05), the numbers was also higher in mild Preeclampsia than control group, difference have statistically significant(P < 0.05).At Cr number, sever Preeclampsia was more higher than mild Preeclampsia and control group, there were statistically significant differences(P < 0.05),while the number of Cr between mild Preeclampsia and control group have no obvious changes, there was no statistically significant differences(P > 0.05). Three groups of pregnant women in the Ur number changes are not obvious, and there was no statistically significant difference(P > 0.05).6.The relationship between UA number and poor perinatal outcomes in pregnant women with preeclampsia:In preeclampsia group, when the serum UA number≥357umol/L, the incidence in preterm birth, low birth weight newborn, fetal distress, asphyxia of newborn and stillbirth was more higher than the serum UA number<357umol/L,difference has statistically significant(P < 0.05).7. The relationship between the serum Cys-C number and poor pregnant outcomes in pregnant women with preeclampsia:In preeclampsia group, when the serum Cys-C number≥1.25 mg/L, the incidence in placental abruption,postpartum hemorrhage was more higher than the serum Cys-C number<1.25 mg/L, there was statistically significant difference(P < 0.05).Conclusion:1. With the development of preeclampsia condition, the time of PT was shorter and the number of PLT was lower, it suggests the blood of patients with preeclampsia was high condensation state.2.Comparsion with mild preeclampsia and normal later period pregnant women, there was more renal damage in severe preeclampsia.3.In patients with preeclampsia, when the serum UA number ≥ 357umol/L, the incidence in poor perinatal outcomes, including preterm birth, low birth weight newborn, fetal distress, asphyxia of newborn and stillbirth and so on,was increased.4. In patients with preeclampsia, when the serum Cys-C number≥1.25 mg/L, the incidence in poor pregnant outcomes, including placental abruption,postpartum hemorrhage and so on, was increased.