Clinical Study Of Metabolism-related Factors And Colorectal Cancer

Objective: Through the 1:1 case- control study, to detect the differernces of metabolic correlation index(BMI, hyperglycemia, dydlipidemia, high blood pressure, hyperuricemia, NAFLD, CHD, D- dimer, TC, TG, LDL-C, HDL-C) among the patients of colon cancer,colorectal adenomas, and the healthy physical examination, so as to discusses whether there is a correlation between colorectal cancer and various metabolic index and whether it is a risk factor for colorectal cancer, and so that can be used to assist in early screening of colorectal cancer.Methods: 75 cases of colon cancer patients were selected as a case group,also 75 cases of colorectal adenoma and 75 cases of normal physical examination were selected as the control group for 2014.10-2016.1 in Affiliated Hospital of Yan’an University.According to the biochemica examination, imaging examination and medical history information, to collect metabolic correlation index and the general conditions of patients, to analysis if there is a correlation between the metabolic indicator and colorectal cancer.Results: 1 There is no significant differernce in age and gender between colorectal cancer group and control group(colorectal adenoma group and normal control group).The incidence of colorectal cancer group was concentrated in the age of 50~75 years old.2 The prevalence of BMI, hypertension, hyperuricemia, NAFLD and CHD in colorectal cancer group are compared with the control group, as a result,there is no statistical differences.3 To compare with matched group,the prevalence of hyperglycemia, dyslipidemia of colorectal cancer group are higher, and there is also no significant statistical differences.4.The levels of D- dimer, TG are higher in colorectal cancer group than the control group, while the standards of TC, LDL-C, HDL-C are lower, and the difference is meaningful..5. By conditional Logistic regression analysis we find that,there is a association between metabolic indicator(high blood glucose, dyslipidemia, D-dimer) and colorectal cancer, and these are the independent risk factors.Conclusion: Colorectal cancer is a disease associated with metabolic disorders, including hyperglycemia, dyslipidemia, D- dimer,and these are independent risk factors. For the average risk population, to screen the risk of metabolic indicators, combinng with colonoscopy, can improve the detection rate of colorectal cancer, so as to we have a assist in early prevention, diagnosis and treatment of colorectal cancer.