To Study On The Correlation Between In Patients With Type 2 Diabetes With High Uric Acid Hematic Disease And The Insulin Resistance

Objectives To investigate the relationship between hyperuricemia(HUA) and insulin resistance(IR) in patients with type 2 diabetes mellitus(DM), and to provide evidence for prevention and treatment of diabetes mellitus complicated with hyperuricemia.Methods Select type 2 diabetes mellitus(T2DM) patients with 227 cases, including 126 cases of male, female 101 cases, age 28 ~ 73 years old in department of endocrinolog affiliated hospital of the North China University of Science and Technology. According to the blood uric acid level of T2 DM with high uric acid group(Case group) 77 cases, 56 males, 21 cases of women, age range was from 28 ~ 73 years old, average age(55.71 + 10.58 years); normal uric acid group(Control group) 150 cases, including 70 cases of male and 80 cases of women, age range was from 32 ~ 70 years old, average age(51.82 + 10.15 years). Hyperuricemia group according to uric acid excretion rate results subdivided for excretion decreased type sub group 43 cases, mixed type sub group 25 cases, increased production type sub group 9 cases. In groups of patients were measured blood levels of uric acid, compared two groups of age, sex, duration of diabetes, Hb A1 c, BMI, FPG, TG, LDL-C, Cr, FPG, FIns, HOMA-IR, diabetes complications. All the data were analyzed by statistical software package SPSS 18.0, The normal distribution of the measure information are expressed as mean ± standard deviation( x ± s), between the two groups compared with independent samples t-test and multiple groups were compared with single factor analysis of variance; count data as a percentage, with by chi-square test; Pearson correlation was used for correlation analysis and draw the correlation coefficient, the risk factors of hyperuricemia in patients with T2 DM wiht non conditional logistic regression model analysis; independent risk factors of hyperuricemia in patients with T2 DM by multiple linear regression analysis. Test standard: P<0.05, the difference was statistically significant.Results Between the two groups in sex, diabetes complications by chi-square test showed that, gender, diabetes complications constitute the difference was statistically significant(P < 0.05). The men in the hyperuricemia group, combined with diabetic complications accounted for a large proportion; three subgroups of hyperuricemia by the chi-square test showed that gender difference was not statistically significant(P > 0.05). Between the two groups in age, duration of DM, BMI, TG, LDL-C, Cr, FPG, FIns,HOMA-IR by t-test showed that hyperuricemia group in the above indexes were higher than the normal uric acid group, the difference was statistically significant(P < 0.05); Hb A1 c between the two groups by t-test revealed differences had no statistical significance(P > 0.05); The FPG 、 FIns 、 FC-P 、 HOMA-IR among the three subgroups of hyperuricemia by single factor variance analysis showed no significant difference(P > 0.05). Between the two groups by chi-square test showed that, hyperuricemia group HOMA-IR is equal to or more than 2.69 cases was significantly higher than the normal uric acid group, the difference was statistically significant(P < 0.05). Taking all the indexes of statistical significance of the chi-square test and the t-test into the non conditional logistic regression model analysis, correcting the influence of age, sex, duration of DM, BMI, TG, LDL-C, Cr, diabetic complications factors showed that risk factors for T2 DM complicated with hyperuricemia is HOMA-IR(OR= 7.237). Pearson correlation analysis showed that serum uric acid level in patients with type 2 diabetes mellitus is positively correlated with age, sex, BMI, TG, LDL-C, Cr, HOMA-IR,(P < 0.05). Put Pearson statistics meaningful indicators into multiple linear regression analysis, the results show that BMI(r = 2.345 P = 0.0030), TG(r = 38.733, P = 0.000), Cr(r = 0.842, P = 0.000), HOMA-IR(r = 11.075, P = 0.000) is positively associated with T2 DM patients with hyperuricemia.Conclusions The rise levels of IR, BMI, TG and Cr are positively related factors of hyperuricemia in patients with T2 DM, and IR is a risk factor for T2 DM in patients with hyperuricemia.