| Research background:Hypertension is a common cardiovascular disease, and a variety of clinical types of diseases, and the incidence of hypertension is closely related to the common heart, brain, kidney, fundus lesions, severe cases can lead to patients with organ failure. Chinese 2015 hypertension treatment guidelines pointed out: cardiovascular disease has become the main cause of death Chinese. Hypertension is the first risk factor. With the accelerated aging process, the prevalence of hypertension increased, and how to deal with the treatment of hypertension has become more and more attention. At present there is no effective drug to fundamentally cure hypertension, but can rely on multiple medications to control blood pressure maintained at a relatively normal level, so it can greatly reduce the incidence of cardiovascular disease and death factors.In recent years, Chinese medicine has made great progress in the prevention and treatment of hypertension, treatment of hypertension with TCM syndrome differentiation and play disease before the early advantage of each link of the necessary prevention of hypertension, interference from many aspects, to prevent hypertension. Through long-term clinical studies at present, hypertension can be divided into: hyperpyrexia, hyperactivity of liver Yang, deficiency of kidney yin deficiency of yin and yang two, four card type, according to different syndromes have different corresponding prescriptions, including nuhuangjiangya pill(capsule) is commonly used in clinical medicine for liver inflammation, has accumulated a large number of relevant nuhuangjiangya pill clinical research, but the lack of a relatively uniform the meta analysis. With the development of evidence-based medicine provides a good solution to this problem: randomized clinical trials of a comprehensive collection of Niuhuang Jiangya pill in the treatment of hypertension, using strict Inclusion and exclusion criteria selected to meet the quality standards of the literature, quantitative or qualitative analysis, obtained in the evaluation of clinical efficacy and safety of Niuhuang Jiangya pill.The purpose of the study:Of Niuhuang Jiangya pill in the treatment of primary hypertension the efficacy and safety of evaluation system, to better guide clinical staff carries on the standardized and effective application.Research methods: computer retrieval of Chinese biomedical literature database(CBM), CNKI Chinese journal full text database and Wanfang database and selected to meet the requirements of Niuhuang Jiangya pill in the treatment of hypertension clinical randomized controlled trials, application RevMan5.3 of included studies were strictly meta analysis.The results of the studyThrough the search to collect a total of 163 papers of Niuhuang Jiangya Capsule(capsule) of the experimental research, through preliminary screening and careful reading of the literature, the analysis included a total of 6 papers of Niuhuang Jiangya Capsule(capsule): a randomized controlled trial. It is divided into 4 parts and the research of single drug drug combination of 2, the former a total of 634 patients were enrolled, including 362 cases of Chinese medicine treatment group, western medicine group of 272 cases, which included 150 patients with the combined treatment group were 75 cases, single western medicine treatment group were 75 cases. 3 of systolic and diastolic blood pressure pressure changes were the combined effect of the amount of analysis of the single drug group the systolic blood pressure, changes in the value of the combined effect of the amount of results: [MD=-0.10,95%CI(-19.85,19.66), the results were not statistically significant p=0.99, nuhuangjiangya pill and Western medicine than in the reduction of systolic pressure difference; sensitivity analysis, the analysis results are affected The study on the analysis of the other two cases removed, changes of systolic blood pressure values of the combined effect of the amount of [MD=-10.59,95%CI(-19.80,-1.38), p=0.02, suggesting that nuhuangjiangya pill and Western medicine in hypertension curative effect is better than that before and after the analysis of the results are not consistent, so the Chinese medicine group decreased systolic blood pressure and efficacy of Western medicine group the effect can not make effective judgment, on the analysis of the combined effect of the amount of diastolic pressure values: [MD=1.57,95%CI(-5.83,8.96) P=0.68.], the results have statistical significance, suggesting that nuhuangjiangya pill and Western medicine than in lower diastolic blood pressure showed no difference. Analysis of the antihypertensive effect of the combined effect of the amount of [RR=1.20,95% C I[0.90,1.58], P=0.21; the results were not statistically significant. The Chinese medicine group and Western medicine group to improve the curative effect of clinical symptoms showed no difference. The combined effect of the amount of [RR=2.17,95%CI(0.73,6.47)], the P=0.21. result was not statistically significant, The symptoms were no difference. The combined effect of the amount of analysis of the combination of the value of systolic blood pressure: [MD=--3.60,95%CI(-10.44,3.24)], P=0.06. showed not statistically significant, suggesting that the effect of Niuhuang Jiangya pill combined with Kato Pury and Kato Pury alone in reducing systolic blood pressure showed no difference. Analysis of the combined effect of the amount of change in systolic blood pressure value: [MD=-3.00,95%CI(-6.14,0.14)], P=0.30. effect of Niuhuang Jiangya pill combined with Kato Pury and Kato Pury alone in reducing the diastolic pressure. There is no difference antihypertensive effect analysis efficiency with: nuhuangjiangya pill combined with Kato Pury and nuhuangjiangya pill combined with amlodipine in improving the efficacy of clinical symptoms is better than Kato Pury or amlodipine alone the horizon.research conclusionAccording to the results of this study showed that Niuhuang Jiangya capsule group and Western medicine group in reducing systolic blood pressure cannot be determined, lower diastolic blood pressure of the two groups showed no difference. The efficiency and clinical symptoms improvement also had no significant difference in the buck; combined treatment group in lower systolic blood pressure and diastolic blood pressure had no significant difference, but in the improvement of clinical symptoms efficacy of combination therapy is better than single western medicine control group. |
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