Design,Synthesis And Biological Activities Of Novel Neuroprotective Agents For Acute Stroke

Acute ischemic stroke is one of the major causes of death.Many pharmacological treatments by means of so-called neuroprotective drugs such as glutamate receptor antagonists and Ca and/or Na channel blockers have been tried;however,they have not been successful in improving clinical outcome in patients.In order to explore new neuroprotective compounds,thirty novel cinnamide derivatives have been designed and synthesized by using computer-aided drug design and their structures were characterized by1H NMR,13C NMR and HRMS.The preliminary pharmacological screening of all the compounds showed that the compounds DZH-1 exhibited potent neuroprotective effects.Futher bioassay and structural optimizing of these cinnamide derivatives as neuroprotective agents are in progress.