Breast Cancer After Neoadjuvant Chemotherapy Liver Damage CT Perfusion Studies

Aim: CT perfusion imaging(CT perfusion imaging, CTPI) Technical changes neoadjuvant chemotherapy in breast cancer patients after liver hemodynamics. Analysis of neoadjuvant chemotherapy cycle parameter changes affect liver perfusion and liver perfusion parameters change characteristics, the observation of early diagnosis and treatment of disease and the efficacy of proposed reliable imaging evidence.Materials and Methods: The study included 60 cases of breast cancer patients in the experimental group, another negative control group included 12 cases.Comparative analysis of the experimental group(receiving neoadjuvant chemotherapy and a course of treatment 2) and CT perfusion parameters of the negative control group, including the time-density curve(time density curve, TDC), hepatic perfusion index(hepatic perfusion index, HPI), permeability surface resistance(permeability-surface area product, PS), and mean transit time(mean transit time, MTT).Experimental group grouped neoadjuvant chemotherapy cycle, analysis of chemotherapy treatment cycle and the impact of changes in liver perfusion characteristic parameters, and to analyze the experimental group CT perfusion parameters, treatment cycle and serum alanine aminotransferase levels(alanine amino transferase, ALT) between relationship, study its relevance.Results: 1. Reference organ TDC curve analysis obtained earlier than the control group TTP value of treatment group 1 and group 2 treatment; △PV value is higher than the control group, the experimental group.2. The experimental group and negative control group HPI, PS and MTT perfusion parameters analysis P values were greater than 0.05, has no statistically significant differences.3. The experimental group 2 cycles of neoadjuvant chemotherapy in patients with HPI(29.87%±6.07%), MTT(26.32±5.53s) representing a course of neoadjuvant chemotherapy in patients(26.53%± 4.65%,21.68 ± 5.78s) and negative control group(25.46%±7.56%,19.78±5.25s) significantly increased, P values were less than 0.05.1,2 treatment group and the control group value PS,P greater than 0.05,no significant difference statistically significant.4. perfusion parameters PVP value increases with chemotherapy treatment decreased in the control group, treatment group, treatment group 2 PVP values were compared, the test results t= 4.58, P= 0.01, with a statistically significant difference. ROC curve analysis PVP value of chemotherapy after diagnosis of liver damage sensitivity and good specificity.5. The experimental group of drug-induced fatty liver patients whose HPI(31.58%±7.05%) compared with non-fatty liver group(25.67%± 4.32%) and negative control group(26.58%±7.23%) increased, P values were less than 0.05.6. The experimental group patients neoadjuvant chemotherapy cycle and HPI, MTT has a significant correlation. r HPI = 0.30, r MTT = 0.40, P values were less than 0.01.Conclusion: CTPI in this study used a comprehensive evaluation of hepatic blood perfusion detection and treatment of liver damage after chemotherapy treatment. CTPI parameters HPI, MTT can alter liver hemodynamics quantitative analysis, and liver damage caused by hemodynamic changes with a certain relevance. Perfusion index PVP has a high diagnostic value of the degree of liver damage, and the extent of liver damage caused by chemotherapy treatment evaluation with high sensitivity.