Correlational Study On Traditional Chinese Medicine Syndromes And Conventional Ultrasound With Histopathologic Grade On Cirrhosis In Patients With Viral Hepatitis

Objective:The study is based on the theory of TCM syndromes and conventional ultrasound and pathology of hepatitis cirrhosis.In order to search cirrhosis,different TCM syndromes related objective criterion or quantitative standard,and improve clinical spread value of traditional integrated western medicine for the treatment of the disease,by exploring the relationship between different TCM syndromes and conventional ultrasound with histopathologic grade.Methods:Making analysis on 75 cases of hepatitis cirrhosis collected in the first affiliated hospital of Guangxi university of Chinese medicine from Jan 2013 to Jan 2015 by using the retrospective method.At the same time,collecting 8 cases of normal subjects as the control group were included in the study.According to the the consensus statement on clinical diagnosis and treatment of cirrhosis written by the top-level experts in Chinese interactive medicine association,TCM Syndrome Differentiation types are six,such as liver qi stagnation,dampness and water resistance inside,accumulation of damp-heat,liver kidney-yin eficiency,kidney-yang deficiency spleen,and blood resistance network.To formulate clinical case report form,record the symptoms,signs,tongue demonstration,pulse tracings liver tissue pathology classification and abdominal ultrasound examination indexes,etc.One TCM attending physician and a TCM chief physician would final decide the types of syndromes of TCM.The data was analyzed with statistical description,chi-square test by SPSS 19.0 statistical software.Results:1.There no difference between the gender,age,virus hepatitis type and TCM different syndromes in hepatitis patients(P>0.05).2.TCM syndrome and conventional ultrasound relations.(1)There were many remarkable different diameter of the portal vein(Dpv)and thickness of spleen between every type of hepatocirrhosis and the control group,P<0.05.The low-to-high change of Dpv on every type is liver qi stagnation <dampness and water resistance inside <accumulation of damp-heat<liver kidney-yin deficiency<kidney-yang deficiency spleen<blood resistance network.The low-to-high change of thickness of spleen on every type is blood resistance network<liver qi stagnation <dampness and water resistance inside <accumulation of damp-heat<liver kidney-yin deficiency<kidney-yang deficiency spleen.(2)There were many remarkable different Types of the liver parenchyma among all type of hepatocirrhosis(P<0.05).The syndrome types of liver qi stagnation,accumulation of damp-heat and dampness and water resistance inside had displayed subtlety in the liver parenchyma types of fine and uniform or the liver parenchyma type of enhanced and thickening.The syndrome type of kidney-yang deficiency spleen had displayed mostly in the liver parenchyma type of enhanced and thickening.The syndrome type of blood resistance network had displayed subtlety in he liver parenchyma types of enhanced and thickening or the liver parenchyma type of coarse nodules.3.TCM syndrome and histopathologic grade.By comparing one to another,it found that there was little different liver tissue inflammation grade(G)of spleen among all types of hepatocirrhosis(P>0.05).The syndrome type of liver qi stagnation had displayed subtlety in G2.The syndrome types of accumulation of damp-heat and dampness and water resistance inside had displayed subtlety in G3 and G2.The syndrome type of liver kidney-yin deficiency had displayed subtlety in G3.The syndrome type of kidney-yang deficiency spleen had displayed subtlety in G4.The syndrome type of blood resistance network had displayed subtlety in G3 and G4.Conclusions:There was a certain correlation between different TCM syndromes and conventional ultrasound with histopathologic grade in patients with posthepatitic cirrhosis.diameter of the portal vein,thickness of spleen,types of the liver parenchyma might be used as the objective indicator of TCM syndrome differentiation type.The study reflected that indexes mentioned above had important reference value to analyze syndrome differentiation of TCM and early diagnosis of posthepatitic cirrhosis.