Xie Zhuo Jie Du Tang On Nonalcoholic Fatty Liver And Leptin (Leptin,LP) Clinical Observation

Background:Nonalcoholic fatty liver disease(NAFLD)is one of the common clinical digestive system diseases,the incidence rate is rising year by year,become a serious common hazards on human health,so people pay more attention to.The study observed the clinical therapeutic effect of Xiezhuo Jiedu Tang in the treatment of non alcoholic fatty liver and the serum leptin(Leptin,LP)the effect of NAFLD to provide a scientific basis for Chinese medicine treatment.In the treatment of NAFLD,because the medicine is the treatment of single target,while Chinese medicine is about syndrome differentiation and treatment,the overall concept,which is the comprehensive analysis of relevant factors,prescription,more in line with the pathogenesis of NAFLD.The treatment of non alcoholic fatty liver of Traditional Chinese medicine,from the point of view of the whole patient,or according to the constitution of the patients,or a combination of disease cause and the law,a comprehensive regulation imbalance of yin and Yang Qi and blood,curative effect is exact,and less toxicity,shows broad prospects in the treatment of nonalcoholic fatty liver disease by traditional Chinese medicine.Objective:This topic discusses xiezhuo tang on nonalcoholic fatty liver and leptin(Leptin,LP)clinical observation,provide the scientific basis for TCM treatment of NAFLD.Methods:According to the Chinese Medical Association of liver disease will develop nonalcoholic fatty liver disease diagnosis and treatment guidelines(2006)diagnosis standard,collecting 2013.11-2014.12,my courtyard outpatient service and hospitalization in patients with nonalcoholic fatty liver disease in 80 cases.Age and sex matched,all cases were non autoimmune disease,acute infectious disease or tumor.By myself a graduate student on general status of all research objects:gender,age,past history,weight,history etc.Comparison of color Doppler ultrasound before and after discharging Xie Zhuo Jie Du Tang in the treatment of NAFLD,serum lipids(total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,very low density lipoprotein),liver function(alanine aminotransferase,aspartate aminotransferase,gamma glutamyl transpeptidase,alkaline phosphatase),body mass index(BMI),serum leptin(LP)and other indicators.Two groups of patients were given healthy lifestyle guidance,such as liver function appropriate for aerobic exercise,alcohol,eat low-fat and low carb diet,eat more fruits and vegetables,control calorie intake,weight control.The treatment group:xiezhuojiedu Decoction(Fuling 20 g,12g of Radix Bupleuri,hawthorn 12 g,huzhang 12 g,Alisma 12 g,Artemisia capillaris 20 g,Perrin 15 g,wine rhubarb 9g,Fructus 12 g,Polyporus 12 g,dandelion 15 g,peel 12 g,tangerine peel 12 g,Radix Salvia miltiorrhiza 20g),boiling water 2 times,take juice 400 ml,daily in the morning and evening two clothes.The control group-Atorvastatin Calcium Tablets(20mg Lipitor)orally,1 times every night.Treatment time:8 weeksThe establishment of the database using SPSS 13 statistical software.Measurement data using t test,or percentages compared with test.Multivariate analysis using non conditional Logistic regression analysis,P<0.05 was a statistically significant difference.Results:1 Xiezhuojiedu tang on clinical efficacy in patients with non alcoholic fatty liver in the Atorvastatin group quite,no significant difference(P>0.05).2 Xiezhuojiedu tang can obviously reduce the level of serum leptin.3 Xiezhuo Jiedu tang have no side effect,atorvastatin calcium group have side effects.Conclusion:1 Xiezhuojiedu tang on nonalcoholic fatty liver disease clinical curative effect of atorvastatin calcium group,the difference has statistical significance.(P<0.05)2 Xiezhuojiedu tang in treating Nonalcoholic fatty liver disease with no adverse events occurred,suggesting that the decoction of compound chinese medicine preparation for safe non-toxic side effects.3 Leakage of serum leptin in patients with xie zhuo jie du tang on nonalcoholic fatty liver disease by reducing the role of.