The Correlation Research Of The Serum Branched Chain Amino Acids,Adiponectin Level And Coronary Heart Disease(CHD) In The Non-diabetic Patients

Backround:Nowdays,the coronary heart disease(CHD) is still the main disease that can threat to human health in around the world. Currently, many studies have confirmed that many factors have a close relationship with it,and those factors are called THE RISK FACTOR. More and more researchs with animal found that BCCA and APN maybe also contribute something to the occurrence of coronary atherosclerosis. CHD is one of the many causes of diseases, the causes are collectively referred to as a risk factor for coronary atherosclerosis. But currently, prospective clinical study about this aspect is relatively lacking. Therefore,to understand exactly what is the relationship between BCCA,APN and coronary heart disease and other traditional risk factors through a clinical study is very necessary.Objecktives:1. To investigate if there is a exact relationship between the branched chain amino acids and adiponectin with the occurrence of coronary heart disease(CHD) and with the severity of the pathological change of coronary artery in the non-diabetic patients. 2. To investigate the relationship between the concentrations of branched chain amino acids and adiponectin(APN) in plasma with those traditional risk factors for coronary heart disease(CHD),like plasma cholesterol, triglyceride, low density lipoprotein cholesterol(hdl-c), low density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), etc.Methods:Selecting 66 cases of patients without diabetes who they all got a coronary angiography in October 2015 to January 2016 at the the second cardiovascular internal medicine in the first affiliated hospital of GANNAN medical universty.we divided those patients into groups according to the results of coronary angiography.The one group has 31 cases and they were confirmed with CHD,mean age 61.29±7.26 years,and another group has 29 cases as a control group,mean age 63.93±10.25 years, and the last 9 cases are just coronary atherosclerosis, mean age 64.78±12.52 years.The concentrations of branched chain amino acids and adiponectin were measured by ELISA,and analysed the relationship between branched chain amino acids, adiponectin and coronary heart disease(CHD) and the relationship between branched chain amino acids, adiponectin and the severity of coronary lesions. At the same time, analysed the correlation between both branched chain amino acids and adiponectin with the traditional risk factors,The degree of artery stenosis was confirmed by coronary angiographies and assessed quantitatively with Gensini score.Results:The plasma branched chain amino acids levels of coronary atherosclerosis and CHD groups were significantly higher than that of control group respectively,(P<0.05);The plasma adiponectin levels of coronary atherosclerosis and CHD groups were significantly lower than that of control group respectively,(P<0.05);The plasma BCCA levels is negatiate relation with adiponectin,(r=-0.839,P<0.01). As the Gensini score increased,the branched chain amino acids levels increased,(r=0.917,P<0.01),the adiponectin levels decreased(r=-0.812,P<0.01).Conclusion:1. The plasma concentrations of branched-chain amino acids is positive correlated with the severity of coronary artery disease.2. The plasma concentrations of adiponectin is negative correlated with the severity of coronary artery disease.3. The plasma concentrations of adiponectin is negative correlated with ranched-chain amino acids.4. Branched chain amino acids and serum adiponectin may predict the risk of coronary heart disease as a new risk factor and a new therapeutic direction.