Effects On IL-33 And SST2 In Patients With Acute Coronary Syndrome Treatment With Different Doses Atorvastatin During Early After PCI

BackgroundThere are over 1.6 million patients accepted percutaneous coronary intervention therapy each year,the current treatment of percutaneous coronary intervention(PCI)for the treatment of coronary artery disease has become a common method of reconstruction.During this period,Some inflammatory bio-marks have been founded.In this study,asST2 protein receptor ligands,we focus on the IL-33,the member of the IL-1 family,was discovery in 2005,which has relationship with aseptic inflammatory response that before or after PCI.The lack of the membrane structure domain soluble ST2 receptor(sST2)can be used as a decoy receptor,combined with IL-33,with negative regulation of IL-33 / ST2 signaling pathways.Recent research confirmed that the suitable dose of statins can down-regulated the PAPP-a,IL6 and TNF-A’s lever,but the effect of the IL-33 and sST2 in this process is not clear.ObjectiveTo discuss effect about serum IL-33 and sST2 levels of different doses of atorvastatin calcium to treatment ACS patients with and its correlation with the level of inflammation in the body.To explore the effective and safe dose of atorvastatin calcium inhibits the acute inflammatory response of the body,to provide the reference for clinical.Methods75 patients in cardiovascular department from 2015 April to November in the First Affiliated Hospital of Xinxiang Medical University for acute coronary syndrome undergoing percutaneous coronary intervention,in which male 40 cases,female 35 cases aged from 41 to 78 years,mean 59.2± 9.43 years old.75 patients(male 40,female 35)were randomly divided into group A,B and C,Each group with 25 patients.Each patient in three groups was given atorvastatin 20 mg,40mg,80 mg per night dividedly.The treatment can’t be stop until 7 days after percutaneous coronary intervention.In the end,74 patients completed the study,including 40 males and 34 females,all patients were treated by PCI in 24 hours.The patients were admitted to exsanguinate in 1 day before PCI,and 1 day,3 days,7 days after PCI.ELASA was used to detect the concentration of IL-33,hs-CRP and sST2.Results1.The serum levels of hs-CRP were significantly higher in all the patients after PCI compared with the preoperative,and the difference was statistically significant(P<0.01).After PCI,the serum hs-CRP concentration decreased with the extension of treatment time,and the difference was statistically significant(P<0.01).There was no significant difference in the treatment group(P>0.05)between the groups in 1 day before and after PCI.On the 3 days after PCI,the hs-CRP level of each group was different.Compared with the 20 mg group,the 40 mg group’s hs-CRP level was significantly decreased,the difference was statistically significant(P<0.05);The hs-CRP of group C was significantly decreased,the difference was statistically.2.the concentration of IL-33 in 80 mg group was significantly decreased,the difference was statistically significant(P<0.01).7 days after PCI,compared with 20 mg group,there was no significant difference about 40 mg group(P>0.05)and 80 mg group(P<0.01).The concentrations of IL-33 were significantly decreased compared with that of 1 days,and the serum concentrations of IL-33 were significantly increased(P<0.01).There were no significant differences in IL-33 levels between three groups(P>0.05),1 days and Methods 3 days after PCI,and the difference between the three groups was significant(P<0.01).There was a significant dose-effect relationship between atorvastatin and IL-33.3.The sST2 increased in 1 days after PCI than before,but decreased in the other treatment period.And there was no significant difference of sST2 between the three groups.4.The results of this study showed that the levels of serum IL-33 and sST2 were negative in the study period.Conclusions1.The increase of atorvastatin calcium was significantly correlated with the increase of serum IL-33 level in patients with ACS after PCI.2.The decrease of sST2 was not significantly correlated with the increase of atorvastatin concentration.3.Atorvastatin calcium dose in less than or equal to 80 mg per night,the increased therapeutic doses could safety increased ACS patients undergoing PCI perioperative cardiovascular protective factor of IL-33 levels,reduce the sST2 levels.