Social Psychological Factors On The Influence Of Female Leukemia Occurrence And Development

Leukemia is a type of malignant clonal disease of hematopoietic stem cell.According to reports,the incidence of leukemia accounted for sixth position in a variety of tumors among all regions of China.The proportion of female leukemia patients occupy a large part of all leukemia patients.In recent years,studies had found that the occurrence and development of malignant tumors was related to psychological status,personality,mood disorders,lifestyle and other psycho-social factors.Many studies had shown that women and men experience different in psycho-social factors in the same disease.At present,there is little research on the influence of social psychological factors on the developing of leukemia in female patients home and aboard.So this study is aimed at the analyze of social psychological factors of female patients with leukemia and to explore the influence factors on the occurrence and development of leukemia.Objective: This study was designed to investigate the psycho-social influence factors on occurrence and development of leukemia of female patients.Methods: This study is a 1:1 matched case-control study.Patients was selected during December 2014-December 2015 from the Department of Hematology,Second Hospital of Hebei Medical University,Department of Hematology,Fourth Hospital of Hebei Medical University,Bethune International Peace Hospital Hematology,Langfang City Hospital.Eligible 100 patients involved in the study.Healthy control group was chosen from patients’ sisters,age difference is less than 5 years old and lived together from childhood.The questionnaire included Eysenck Personality Questionnaire(EPQ),Symptom Checklist(SCL-90),Life Event Scale(LES).These scales printed and bound,by a uniform training of research staff distribution and recovery questionnaire.All data was use a twice separate entry method to establish a database.SPSS17.0 statistical package was used for statistical analysis.Statistical methods including general descriptive statistics,paired samples t-test and χ2 test.Results:1 Case group and the control group had no significant difference on personality factors(P>0.05),including introversion and extroversion,cover up.Whereas psychoticism,neuroticism were significant different(P<0.05)between groups.Case group appear to have stronger "psychoticism and neuroticism" compere to the control group.2 Negative life events were significantly different in total stimulus on total amount of negative events and family-related issues negative life events between case and control groups(P<0.05).There was no significant difference between the two groups of women negative life events and social and other problems in the amount of negative life events in the work and study(P>0.05)he total amount of negative life events and the total amount of negative life events related to family problems experienced by female patients with leukemia were more than control women.3 The case group and the control group had no significant difference in interpersonal sensitivity,compulsion,terror,paranoid,psychotic(P>0.05).Case group and the control group showed significant difference in somatization,anxiety,depression,hostility(P<0.05).In "somatization,anxiety,depression,hostility" project,the female patient group "somatization,anxiety,depression,hostility" degree were higher compared normal control group.Using the chi-square test,risk factors and relative risk of female leukemia patients were somatization,anxiety,depression,hostility(ORS were 5.489,6.6 77,8.903,2.212).Conclusions:1 Social psychological factors have a certain influence on the development of female leukemia.2 In the aspect of personality,female leukemia patients have higher score on psychoticism,neuroticism than normal female.Female patients with leukemia appear more nervous,anxiety,poor sleep quality,irritability,hostility compare to control.3 Leukemia patients experience more family negative life events and negative life events than in normal women.Also the stimulation were more from negative events of patients group.Patients experience higher psychological pressure that affect the physical and mental health.4 In the condition of psychological health,somatization,anxiety,depression and hostility level in female patients with leukemia was higher than normal women.Female patients with leukemia also always experience dizziness,fatigue and other physical discomfort like anxiety,depression and hostility.Therefore somatization,anxiety,depression,hostility were possible related risk factor to women leukemia.