Shaanxi Han Population Genetic Polymorphisms Associated With The Risk Of Esophageal Cancer Research

Purpose:A large number of contrast studies about people have found that living in different regions and with different racial or ethnic groups, there are many differences between the gene polymorphism, and there are large differences between gene polymorphism to esophageal cancer susceptibility. This study discusses the risk of esophageal cancer and gene polymorphism in Han population of Shaanxi Province, aims to fill the domestic ethnic relations between the gene polymorphism and cancer risk. We adopted a research technique of case-control. Utilizing the epidemiological investigation to esophageal cancer cases in Han population of Shaanxi Province and healthy controls, and combining with the laboratory results, we in depth analyzed the relationship between gene polymorphism and the risk of esophageal cancer in Han population of Shaanxi Province.Methods:We obtained 310 cases of healthy crowd blood samples in Han population of Shaanxi Province and 360 cases of new esophageal disease crowd blood samples, extract genomic DNA from the above samples. We picked out 83 single nucleotide polymorphism loci (SNPs) from the analysis of published literature. The published literatures include genome-wide association study (GWAS) about esophageal cancer and Meta-analysis and other correlation analysis. It is using the mass spectrometry genotype polymorphism point detection technology platform (Sequenom MassARRAY) to Genotyped. Using the chi-square test and SNPStats analysis software for the SNP analyze of parting from experimental results.Results:Based on chi-square analysis, rs971074 (ADH7), rsl0788473 (GRID1), rs2274223 (PLCE1), rs4444235 (BMP4), rs4785204 (HEATR3), rs4822983 (CHEK2), rs4924935 (PRPSAP2) and rs738722 (HSCB) were associated with a significant risk of esophageal carcinoma in the Shaanxi Han population. In the genetic model analyses, we found:rs971074 site and rs4924935 site in they respective optimal model (dominant model) is decreased the risk of esophageal cancer. The OR value and 95% CI is 0.711(0.526-0.962), 0.706(0.5-0.995); rs10788473, rs2274223 and rs4444235 the three sites in their respective optimal model (dominant model) are increased the risk of esophageal cancer. The OR value and 95% CI is respectively 8.677 (6.654-11.316),1.39 (1.075-1.798),1.281 (1.027-1.599); rs4785204, rs482298 and rs738722 the three sites in their respective optimal model (recessive model) are increased the risk of esophageal cancer. The OR value and 95% CI is respective 7.51 (1.84-30.66),1.61 (1.02-2.54),3.37 (1.28-8.89).Conclusions:Our results combined with the previous literature reports, GRID1, PLCE PLCE1, BMP4, HEATR3 and CHEK2, the six genes increase the risk of esophageal cance ADH7 and PRPSAP2 genes to reduce the risk of esophageal cancer, and there are tv protected sites to the risk of esophageal cancer.