Gold-catalyzed Intramolecular Cyclization For The Synthesis Of Indole-benzoxazine Derivatives And The Synthesis Of Iodonated 2-vinylindole Derivatives

Gold catalyst can be efficiently activated carbon-carbon double bond, to achieve rearrangement and cyclic isomerization reaction of different alkenes, alkynes and double alkynes. Electrophilic gold salts are the most effective catalysts to activated alkyne which are often used to build a carbon-carbon bond or carbon-heteroatom bond. Based on gold catalytic organic reactions, we developed gold-catalyzed intramolecular cyclization to synthesis indole-benzoxazine derivatives. We developed the reaction of indole diacetylene alcohol with NIS to synthesis series of multi iodo 2-enyl indole derivatives.The first chapter introduces Au(III) and Au(?) catalyzed organic reactions from different types of reactions.The second chapter studies Au(III) catalyzed N-Boc-2-alkynyl indole intramolecular cyclization to efficiently synthesized series of oxazine-[3,4-a] indol-1-one derivatives, and preliminary study it's fluorescence properties.The third chapter introduces the electrophilic iodination reaction of NIS and indole diacetylene alcohol to synthesis triiodo-substituted 2-enyl indole derivatives in one step.