Synthetic Study On The Key Intermediates For Total Synthesis Of Mifepristone

Mifepristone is widely used for early medical abortion. It is highly efficient and low toxicity. Recently, more and more new clinical uses are reported.The used synthetic routes now for mifepristone are relatively long with low yields. Herein we raised a new route to total synthesize mifepristone. It uses a bicyclo[2.2.1]heptane derivative to achieve stereoselectivity and accomplishes the ABC rings in one step. This new route is very meaningful to low the cost of mifepristone and raises a new idea for the total synthesis of mifepristone and its analogies and other steroid structures.In this paper, two important intermediates of the above novel route 7-[2-(4-Dimethylamino-phenyl)-ethyl]-7-methyl-bicyclo[2.2.1]hept-5-en-2-one and 7,7-o-Phenylendioxy-1-octen-3-on were synthesized.