| Objective:This study was planned to summarize the main clinical and laboratory presentations of Mycoplasma pneumoniae pneumonia in children, find the incidence and relation of Mycoplasma pneumoniae pneumonia and wheeze tertiary hospital of eastern China. The aim of this study was also to find out any possible role of mycoplasma pneumoniae infection in development of childhood asthma.Methods:This was a retrospective study of hospitalized children with the diagnosis of CAP of 3 month to 15 years of age from 1st January 2013 to 31 December 2013; Pneumonia was defined as the presence of fever, acute respiratory symptoms (cough, tachypnoea, difficult breathing) or both, plus presence of new infiltrate on chest radiography. Acute MP infection was determined by clinical presentation and positive results of serologic testing, with specific IgM, IgG present in serum, and/or by positive throat swab culture. Total cases were divided into two categories:MPP and Non-MPP. Hematological examinations include:IgE and MP specific IgG and IgM. Demographic data includes age and sex. Paired t-test or chi square test was performed to identify significant differences of clinical and laboratory findings in MPP and Non-MPP pneumonia.Results:The main presentations of non-mycoplasma pneumoniae pneumonia are fever, cough, and crepitation whereas main presentations of Mycoplasma Pneumoniae pneumonia were fever, cough, and wheeze.Wheeze was presented in 52.3% of MP positive pneumonia (p<0.000). Similarly, IgE increase (>100IU/dl) and wheeze were found more in MP positive children (p<0.000, p<0.05 respectively) compared to non-MP pneumonia children.Conclusions:The present study suggests that wheeze is frequently associated with MP positive CAP in children. Similarly, increase of IgE was found in MP positive pneumonia, demonstrating hyperreactive immunology response. Our study indicates that there may be some role of MP infection in development of atopy and asthma in children. |
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