The Relationship Between Serum 25-Hydroxy Vitamin D Level And Peripheral Neuropathy Of Type 2 Diabetes Mellitus

Objective:To investigate the relationship between vitamin D and diabetic peripheral neuropathy by Making a Comparison of serum 25- hydroxy vitamin D levels between diabetic peripheral neuropathy group and non peripheral neuropathy group in type 2diabetes mellitus.Methods:101 patients with type 2 diabetes mellitus from the second hospital of Shanxi medical university were enrolled in this cross-sectional study, we choose Toronto clinical scoring system as the diagnostic criteria for DPN,including diabetic peripheral neuropathy group 52 cases and non diabetes peripheral neuropathy group 49 cases.The following data were collected from the study patients and control group: Age, gender,duration of diabetes,lipid,Glycated hemoglobin,Microalbuminuria,C-reactive protein,Fasting c-peptide,Fasting plasma glucose;Serum 25-hydroxy vitamin D levels were determined by ELICA.Results:Serum 25-hydroxy vitamin D levels in diabetic peripheral neuropathy group were significantly lower than those in non diabetic patients with peripheral neuropathy [(11.58±6.00) ng/ml vs(14.94±6.07) ng/ml, P<0.01].The frequency of severe 25-hydroxy vitamin D deficiency was significantly higher in diabetic peripheral neuropathy group than that in non diabetic peripheral neuropathy group, the difference was statisticallysignificant(P<0.05); The level of serum 25- hydroxy vitamin D was negatively correlated with the course of diabetes mellitus and HbA1c(r-0.336 and-0.278, P<0.01).Binary logistic regression analysis showed that 25- hydroxy vitamin D was an protective factors for diabetic peripheral neuropathy( OR=0.91, 95%CI 0.833-0.995,P<0.05).Conclusion:Serum 25-hydroxy vitamin D levels in DPN group were significantly lower than those in NDPN group. Vitamin D is one of the protective factors of diabetic peripheral neuropathy, lack of vitamin D may be involved in the occurrence and development of peripheral neuropathy in type 2 diabetes mellitus, patient with long duration and poor glycaemic control are more likely to suffer from vitamin D deficiency.