A Prevalence Survey Of Neonatal Congenital Heart Disease In A Maternity And Child-care Hospital Of Gansu Province

Objective:The purpose of this study is to investigate the incidence of neonate congenital heart disease and to explore the risk factors of CHD. The relationship between risk factors and CHD were accessed so as to provide scientific evidence for congenital heart disease prevention.Methods:Neonates born in a maternity and child-care hospital were diagnosed by echocardiogram from December 2013 to October 2014. Questionnaires designed by National Center for Cardiovascular Diseases were used to collect general data by trained investigators. With a case-control study, all the 73 patients with congenital heart disease were selected as case group. Controls were live births without congenital heart disease selected from the same hospital in the same geographic regions. Screening results of congenital heart disease was described. Logistic regression analysis was used to examine the relationship between factors and the occurrence of congenital heart disease.Results:Of the 2148 neonates, 73 congenital heart disease patients were found with a positive rate of screening of 3.40%.The result of single-factor analysis shows that CHD was associated with history of abortion, weight gain during pregnancy, multivitamin use and age of spouse. The result of multi-factor logistic regression analysis shows that history of abortion, excessive weight gain during pregnancy were risk factors of CHD and multivitamin use, smaller age of spouse were protect factors of CHD.Conclusion:The positive rate of screening of congenital heart disease in Gansu Province was not different from other parts of China. History of abortion was risk factor of CHD. Smaller age of spouse was associated with a reduced risk for CHD. Multivitamin use and weight gain control during pregnancy are important measures in reduce the risk of congenital heart disease.