Observation Of The Changes Of The Structure And Function Of The Macular Area After Vitrectomy In Patients With Idiopathic Macular Hole

Objective To observe the changes of visual acuity, optical coherence tomography(OCT) and multifocal electroretinogram(mf ERG) before and after vitrectomy in patients with idiopathic macular hole(IMH), and explore the sensitive indexes of structural and functional changes in these patients.Methods 34 eyes of 34 patients who underwent vitrectomy from December 2013 to April 2014 in Beijing Tongren Hospital for idiopathic macular hole(IMH) were collected. All patients were followed up for 6 months. BCVA, mf ERG and OCT were examined at baseline, 3 month and 6 month, respectively. The results were analyzed statistically compared with the other eye of patients.Results The patients with idiopathic macular hole suffered a significant reduce in BCVA, as well as mf ERG P wave and N1 amplitude in foveal and perifoveal area(P<0.05). Though the mf ERG parameters gradually recovered after operation, can not reach healthy level. This study also observed that the mf ERG P wave latency delay at 3 months postoperative and recovered at 6 months after surgery. Preoperative BCVA and dmin, dmax are significantly related(ρ=0.549, ρ=0.610, P<0.01),but has no correlation with the parameters of mf ERG; postoperative BCVA and CRT are related(P < 0.05), and no relationship was found between postoperative BCVA and mf ERG parameters.Conclusions The postoperative visual acuity and visual function of eyes with idiopathic macular hole improved. The macular structure and function have a certain degree of recovery. Preoperative and postoperative OCT of main indexes in patients with best corrected vision, preoperative dmin, dmax of patients visual acuity after predictive significance. This study did not find preoperative mf ERG parameters on postoperative best corrected visual acuity has prognostic significance.