Systematic Review Of The Therapeutic Effect Of BCG Polysaccharide And Nucleic Acid Injection Combined With The Second Generation H1 Receptor Antagonist In The Treatment Of Chronic Urticaria

Objective: To systematically evaluate the efficacy and safety of BCG-PSN combined with the second generation H1 receptor antagonist in the treatment of chronic urticaria.Methods: We made a retrieval in Pub Med, Cochrane Library,EMBase, CNKI,Wangfang, VIP for literatures about the efficacy and safety of BCG-PSN combined with the second generation H1 receptor antagonist in the treatment of chronic urticaria from the establishment of some databases to October 2014. RCT comparing BCG-PSN plus the second generation H1 receptor antagonist with the second generation H1 receptor antagonist alone for chronic urticaria were collected in our thesis. Rev Man 5.1 statistical software was employed to conduct systematic review.Results: We included 8 pieces of literature and 853 patients,including experimental group with 437 patients and control group with 417 patients. The meta-analysis showed the following results: the two groups were significantly different in effective rate [OR( 95%CI)=3.49(2.42,5.04),P<0.01];the two groups were significantly different in recurrence rate[OR(95%CI)=0.22(0.12,0.41),P<0.01]; the two groups were not significantly different in the rate of adverse reaction[OR(95%CI)=0.85(0.50,1.43),P=0.53].Conclusions: Compared with the treatment with pure the second generation H1 receptor antagonist, it is more effective and lower recurrence in BCG-PSN combined with the second generation H1 receptor antagonist group, which causes no severe adverse reactions and has favorable efficacy and safety.