The Relationship Between Periostin And Glucolipid Metabolism And Insulin Resistance

Purpose To examine the relationships among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation.Methods A total of 83 patients with newly diagnosed type 2 diabetes mellitus(T2DM) and 78 patients with normal glucose tolerance(NGT) were enrolled and further categorized into normal weight(NW) subgroups and obese(OB) subgroups. Body fat parameters, blood glucose and insulin levels were measured. Body mass index(BMI), waist-hip ratio(WHR) and the homeostasis model assessment of insulin resistance(HOMA-IR) were evaluated. The concentrations of plasma periostin and tumor necrosis factor α(TNF-α) were detected using ELISA.Results Plasma periostin levels in T2 DM group was significantly higher than that in NGT group(P<0.01), patients with both OB and T2 DM have the highest periostin concentrations.Correlation analysis showed that plasma periostin levels were positively correlated with weight, WC, WHR, BMI, FPG, 2hPG, HbAlc, TG, TC, FINS, HOMA-IR and TNF-α(P<0.05 or 0.01), and negatively correlated with HDL-c(P<0.01). Multiplelinear regression showed that TG, TNF-α and HOMA-IR were independent related factors in influencing the levels of plasma periostin( P<0.01).Conclusion In conclusion, Chinese patients with obesity and type 2 diabetes had a significantly higher plasma periostin concentrations, and plasma periostin concentrations were strongly associated with plasma TG, chronic inflammation and insulin resistance.