Clinical Analysis Of Very Low Birth Weight Infants In Chinese And French Hospitals

Objective: To compare the clinical characteristics and outcomes of very low birth weight infants in Chinese and French hospitals.Methods: A retrospective study was conducted for VLBWIs admitted into Hospital of Haute Pierre of Strasbourg University(HHPSU) and Children’s Hospital of Chongqing Medical University(CHCMU) within 24 hours after birth from January 2014 to July 2015. The patients were divided into three groups according to their birth weight to compare clinical characteristics, cause of premature, incidence of complications and cause of death.Results: A total of 236 VLBWIs(120 males, 116 females) of HHPSU were enrolled. The average gestational age was(28.8±2.6) weeks and birth weight was(1046.4±264.2)g. 215 VLBWIs(104 males,111 females) of CHCMU were enrolled. The average gestational age was(30.9±2.7) weeks and birth weight was(1246.5±188.8) g. The main causes of premature in two hospitals were maternal hypertension, premature rupture of membrane(PROM), multiple gestations. Administration of antenatal corticosteroids and the usage of pulmonary surfactant(PS) in delivery room were significantly higher in HHPSU than in CHCMU(P<0.05). The times of using PS in HHPSU is higher in CHCMU(P<0.05). There was no significant difference in the incidence of patent ductus arteriosus(PDA)(P>0.05), but the usage of ibuprofen was significantly higher in HHPSU than in CHCMU(P < 0.05). The incidence of pulmonary hypertension and pulmonary hemorrhage were significantly higher in CHCMU than in HHPSU(P<0.05). There was no significant difference in the incidence of culture-positive sepsis, retinopathy of prematurity(ROP) and intraventricular hemorrhage(IVH)(≥ grade II)(P>0.05). The survival rate of HHPSU(92.80%) was significantly higher than in CHCMU(56.74%)(P<0.05). The main cause of death in HHPSU were septic shock(35.29%) and severe IVH(29.41%), whereas in CHCMU were neonatal pulmonary hemorrhage(25.81%) and neonate respiratory distress syndrome(NRDS)(16.13%).Conclusion: Both HHPSU and CHCMU need to strengthen the monitoring of high-risk pregnancies, reducing the birth rate of VLBWI infants. In our country, we should enhance the administration rate of antenatal corticosteroids and early surfactant therapy, make neonatologists available in delivery room. Early diagnosis and treatment of PDA and pulmonary hypertension are important to improve the survival rate.