A Clinical Analysis Of 274 Cases Of Neonatal Necrotizing Enterocolitis

Objective: To explore the influencing factors of neonatal necrotizing enterocolitis(NEC) and to prov ide theoretical basis for its early intervention.Methods: Incorporated in January 2008 to December 2012 12 hospitals in Pearl River Delta,northern Guangdong, western Guangdong general hospital and maternal and child health care institute hospitalized children with NEC 274 cases were retrospectively analyzed, questionnaire design, on the general situation, pregnancy, birth history, classification of newborn, prior to the onset of the illness, NEC clinical manifestations, feeding status, discharge diagnosis, and ending in the aspects of recording and analysis, premature and full-term infants groups were compared, and according to the prognosis for cure group and worsening group of factors related to the multi factor Logistic regression analysis.Results: 1.The pathogenesis characteristics: all patients with ethnic Han nationality, including 164cases(59.85%) of male and 110 cases(40.15%) of female, 177 cases(64.59%) of premature infants;in throughout the neonatal period range have the disease, which within 10 days after the onset of have 212 cases(77.37%).2.Cure group and contrast group deterioration: NEC cure group and the deterioration of the group of single factor comparison: shock, staging, milk speed, milk time,non nutritive sucking, and gestational age of the corresponding P values were less than 0.05, with statistical significance. Comparison of NEC in preterm and term infants, preterm infants appear preeclampsia, premature rupture of membranes, PDA, metabolic acidosis, plasma, red cells,,frequent episodes, NRDS, anemia, hyperbilirubinemia is significantly higher than that of full-term infants of apnea, the difference was statistically significant(P < 0.05)).3.Multivariate logistic regression analysis showed: shock, staging, milk speed are the risk factors influencing the prognosis of NEC, PDA, with milk speed are the risk factors influencing the prognosis of NEC in preterm infants, fed with formula milk and milk speed is the risk factors affecting the prognosis of full-term infants NEC; milk time, non nutritive sucking, gestational age is the protective factors of influencing the prognosis of NEC, non nutritive sucking is protective factors of influencing the prognosis of NEC in preterm infants, milk time is a protective factor for influencing the prognosis of NEC full-term infants.Conclusions: 1. For 5 years, NEC was seen more in preterm infants, the most common disease occurred within 10 days after birth, and the occurrence of NEC is usually the result of multiple factors.2.The factors affecting the prognosis of NEC: shock, staging, milk speed, milk time, non nutritive sucking, and gestational age; in preeclampsia, premature rupture of membranes(PROM),,PDA, metabolic acidosis, plasma, red cells, NRDS, anemia, hyperbilirubinemia, premature than in full-term infants more prone to NEC; compared with full-term infants, NEC in preterm infants are more likely to have frequent episodes of apnea.3.Effect of NEC prognosis risk factors: shock,staging, milk rate; risk factors influencing the prognosis of NEC in preterm infants: PDA, with milk rate; risk factors affecting the prognosis of full-term infants NEC has: fed with formula milk and milk speed.4.Protective factors influencing the prognosis of NEC: milk time, non nutritive sucking,and gestational age; protective factors of influencing the prognosis of NEC in preterm infants: non nutritive sucking.