Impact Factors Analysis Of CHB Nonalcoholic Fatty Liver Disease

ObjectiveIn this study, the epidemic characteristics of CHB with NAFLD are explored, and the impact factors resulted in CHB with NAFLD are discussed. From the above analysis, a scientific basis of the treatment programs is provided to clinicians which can decrease the incidence rate of CHB with NAFLD and increase the treatment efficacy and the life quality about the patients. MethodsThe study samples include 323 patients with CHB which are from the third hospital of Jincheng City from June, 2010 to June, 2015. 323 patients are classed two groups based on Hepatobiliary and pancreatic ultrasound: 107 patients with CHB and NAFLD as epidemic group and the rest 216 patients as the comparison group. Body Mass Index(BMI), ALT, TBi L, LDL, TG,UA, FBG, HBsAg, HBeAg and HBV-DNA are examined. The examined results of Hepatobiliary and pancreatic ultrasound are also considered.Impact factors, biochemical Indicators, viral load are analyzed by statistical methods, such as single factor analytical method, test and Logistic regression model. Results1.There is no significant(p>0.05) difference of the ages between epidemic group and comparison group with 45.21±8.57 and 44.82±12.45 years old, respectively.2.A significant difference(p<0.05) is found between them for some key indices, such as BMI=27.10±3.07 kg/m2, blood sugar=5.96±1.76 mmol/L and LDL=3.66±1.06 mmol/L for epidemic group, and BMI=23.75±2.92kg/m2, blood sugar=5.46±1.64mmol/L and LDL=2.19±0.94mmol/L for the comparison group.3.According to the single factor analytical method of CHB with NAFLD, it shows that there exists significant difference of BMI≥28kg/ m2, HBVDNA≥5log10,HBe Ag(+) and male with age bigger than 40years(p<0.05). While the fasting plasma glucose ≥7.0mmol/L is not the risk factor.4.Furthermore, some key factors(such as age, gender, BMI, Triglycerides, LDL, alanine aminotransferase and total bilirubin) obtained by the single factor analytical method are introduced in the Logistic regression model. The increase of Obesity, triglycerides and low-density lipoprotein is single risk factor. However, the increase of Alanine aminotransferase and total bilirubin is not the risk factor(p<0.05). Conclusions1.The CHB patients with NAFLD have a high percentage(33.13%) which is consistent with that of the other countries.2.High body mass index, high triglycerides and high LDL levels are the risk factors of Hepatic steatosis.3.Some other impact factors of Hepatic steatosis should be explored for further research, such as viral load of HBV DNA, positive of HBeAg and male.