The Study Of The Correlation Between HBc-Ab Positive Occult HBV Infection And Liver Cirrhosis

ObjectiveAim to analysis the correlation between HBc-Ab positive occult HBV infection and lliver cirrhosis and understand the clinical characteristics of OBI. is To demonstrate HBc-Ab positive OBI is one of the risk factors for cirrhosis. Participants and MethodsTo collect 9761 patients who met the inclusion and exclusion criteria in The second hospital of Shanxi medical college between 2012.11.01 and 2015.05.01. There were 2238 patients in case group(HBsAg-HBcAb+), 621 patients in positive control group(HBsAg+), 6902 patients in negative control group(HBsAg-HBc Ab-). Collecting the clinical data of all patients in detail including HBV makers, liver function, coagulation function, diagnosis and so on. Using statistical software SPSS 17.0 processing data. Measurement datum were shown in mean ± standard deviation. Compared the rate by chi-square test and calculated the OR value. Trend chi-square test was used for analyzing the correlation between the titer of HBcAb and liver cirrhosis. Kruskal-Wallis Test was used for comparisons among plurality of independent samples. Kendall correlation coefficient was used for analyzing the correlation between the titer of HBcAb and liver function, coagulation function. P < 0.05 was considered statistically significant. Results1.The incidence of liver cirrhosis in positive control group is 14.33%, in case group is 1.072%, in negative control group is 0.507%.2.HBsAb and HBeAb are confounding factors. They are protective antibodies.3.The titer of HBcAb has nothing to do with the incidence of liver cirrhosis.4.The serum albumin in case group and positive control group are lower than negative control group. There is no difference between the serum albumin in case group and positive control group.5.ALT, AST and TBIL in case group are higher than negative control group, are lower than positive control group.6.PT and APTT in case group and positive control group are higher than negative control group. There are no differences between case group and positive control group.7.PTA in case group and positive control group are lower than negative control group. There is no difference between case group and positive control group.8.The titer of HBcAb has nothing to do with serum albumin, ALT, AST, TBIL, PT, APTT, PTA.9.The titer of HBcAb has nothing to do with HBsAb. A positive correlation was shown between the titer of HBcAb and HBe Ab. Negative correlations were shown between the titer of HBcAb and HBsAg、HBeAg. Conclusion1. HBc-Ab positive OBI is the risk factor of liver cirrhosis but the titer of HBcAb has nothing to do with the incidence of liver cirrhosis.2.HBsAb and HBeAb are protective antibodies.3.The serum albumin in case group and positive control group are lower than negative control group. There is no difference between the serum albumin in case group and positive control group. ALT, AST and TBIL in case group are higher than negative control group, are lower than positive control group.4.PT and APTT in case group and positive control group are higher than negative control group. There are no differences between case group and positive control group.PTA in case group and positive control group are lower than negative control group. There is no difference between case group and positive control group.5.The titer of HBcAb has nothing to do with serum albumin, ALT, AST, TBIL, PT, APTT, PTA.6.The titer of HBcAb has nothing to do with HBsAb. A positive correlation was shown between the titer of HBcAb and HBe Ab. Negative correlations were shown between the titer of HBcAb and HBsAg、HBeAg.