The Relationship Between Simple Renal Cyst And Hypertension

ObjectiveWe analyze the clinical characteristics and determine the impact of simple renal cyst (SRC) on arterial blood pressures, in order to understand the relationship between SRC and hypertension.MethodsIn this study, a total number of 91433 participants were included, who underwent health examinations during 2012-2014. We recorded their main life styles, arterial blood pressures, renal ultrasound test results and other clinical features of each participant, and recognized the SRC patients from all participants. Then we analyze the relationship between arterial blood pressure and the clinical features of SRC. Meanwhile we select participates of control group with age and gender of SRC participants to do 1 to 3 matched case-control study and multiple logistic regression analysis to analyze the relationship between SRC and hypertension.ResultsWe totally found 2465 SRC patients in our cohort. The occurrence of SRC in this cohort was 2.70%, which was higher in men than in women (2.95% vs1.68%; P=0.01). Several clinical parameters were significantly higher in the SRC group than in the SRC-na(?)e group, including age, male rate, GLU,TC, Cr, BUN, the systolic blood pressure and diastolic blood pressure, as well as the rates of hypertension history, kidney stone positivity and urinary protein positivity (all PsT 0.01).But the GFR was lower in the SRC group(Pt 0.01). The occurrence of SRC, multiple SRC, renal stone and positive urine proteirl PT 0.01」 and the maximum diameter of SRC」 P=0.04」 are much higher in renal dysfunction group than normal renal function group. In the cohort of renal stone we found that maximum diameter of SRC is smaller in the group without renal ston」 PT 0.01」 Within the SRC group, patients with hypertension had larger maximum diameter of SRC (2.66e1.89cm vs 2.55e1.55cm; P=0.03) and the prevalence of bilateral SRC (7.05% vs 5.1%; P=0.04) than those without hypertension. We also found that the OR of age, gender, blood glucose, BUN, gfr, positive urine protein, renal stone is 1.04↑↑1.86↑↑1.04↑↑1.01↑↑0.98↑↑ 1.25↑↑4.53 in the result of multiple logistic regression analysis that made SRC as a dependent variable all PsT 0.01」. Multivariate logistic regression analysis further showed that the hypertension was positively correlated with the rates of bilateral SRC and kidney stone (OR=1.14,1.25, respectively; Both Ps<0.01). Matched analysis expressed that Several clinical parameters were significantly higher in the SRC group than in the SRC-na(?)e group, including the systolic blood pressure and the rates of hypertension familial history, as well as, the prevalence of hypertension, kidney stone positivity and urinary protein positivity」 137.39e20.31,135.90e19.30mmHg; 17.00,14.50%; 58.82, 50.71%; 7.06,1.58%; 7.46,3.61%; Ps<0.01J. But the glomerular filtration rate was lower in the SRC group[79.01e19.89tT84.68e18.62mL/(?) minX1.73 m2」(?)P<0.01]. While we also found that there is no significant difference between these two groups in diastolic blood pressure」85.56e10.97↑↑84.60e10.57mmHg(?)P>0.05(?). Multiple factor analysis ex pressed that the OR(95% CI) of SRC group is 1.18(1.11-1.25), and SRC is correlated with the increase of systolic blood pressure1 B=2.47, (?)=0.05, P<0.01」 ConclusionSRC easily occurs in old man. While SRC is a risk factor to make renal function decrease, which expressed by GFR a renal function change sensitive parameter. SRC will mainly make change of systolic arterial pressure. It’s an important risk factor of systolic hypertension.