The Correlation Research Of Serum NSE And S100B Protein With The Severity And Prognosis Of Acute Spinal Cord Injury

Objective: To determine the course of NSE and S100 B protein in patients with acute spinal cord injury and observe a possible relationship between the improvements of neurological function and biomarker levels.Methods: Samples including 27 cases of patients with acute spinal cord injury, serum levels of NSE and S100 B protein were measured on the day of injury and after injury 2d、3d、4d、5d、6d、7d、8d、9d、10d by using ELISA, and evaluated neurological function on admission and followed for 6 months.Results: In patients with AIS improvement group, serum NSE levels rose to the highest at 2d(t=34.98, P<0.05) after injury, then overall declined. In patients without AIS improvement group, serum NSE levels rose to the highest at 3d(t=25.48, P<0.05) after injury. Serum NSE and S100 B protein levels were both significantly increased in patients with AIS improvement group and patients without AIS improvement(P<0.05), and patients without AIS improvement had significantly higher NSE and S100 B protein levels compared with patients with AIS improvement(t=7.15, P<0.05; t=5.18, P<0.05). Serum NSE protein level were negatively correlated with the ASIA sensation score of patients admitted to hospital, and negatively correlated with the recovery rate of sensation, and the difference was statistically significant(r=-0.70, P=0.04; r=-0.86, P<0.01). Serum NSE protein level were negatively correlated with the ASIA motor score of patients admitted to hospital, and negatively correlated with the recovery rate of motor, and the difference was statistically significant(r=-0.59, P<0.01; r=-0.93, P<0.01). Serum S100 B protein level were negatively correlated with the ASIA sensation score of patients admitted to hospital, and negatively correlated with the recovery rate of sensation, and the difference was statistically significant(r=-0.72, P=0.03; r=-0.85, P<0.01). Serum S100 B protein level were negatively correlated with the ASIA motor score of patients admitted to hospital, and negatively correlated with the recovery rate of motor, and the difference was statistically significant(r=-0.71, P<0.01; r=-0.92, P<0.01).Conclusion: 1. The early elevation of serum NSE level in patients with acute spinal cord injury may be a bad prognostic signal. 2. The levels of serum NSE and S100 B protein in a certain extent reflect the severity of acute spinal cord injury, and to evaluate the prognosis of acute spinal cord injury has great value, is conducive to explore the potential to treat acute spinal cord injury.