Serum Bilirubin, Blood Lipid And Homocysteine In Patients With Silent Cerebral Infarction

ObjectiveTo detect serum bilirubin, blood lipid and homocysteine in patients suffering from silent cerebral infarction(SCI). To investigate the correlation between the serum levels of every above-mentioned index and SCI.MethodsSubjects 100 patients(46 men,54 women, age range 42-75 year, average age 61±8.83 year) with SCI were analysed retrospectively between November, 2013 and December, 2014. 100 healthy subjects(48 men,52 women, age range 41-74 year, average age 62±9.15 year) served as the control.SCI group inclusion critera: All had infarcts, confirmed by head MRI,wheather they had history of cerebral infarction or not. Neurological examination did not locate signs consistent with lesions of the nervous system.SCI group exclusion critera:(1) the obvious liver and renal insufficiency;(2) acute myocardialinfarction and other vascular embolic disease;(3) hyperthyroidism and other chronic wasting disease;(4) recent infection, autoimmune disease, estrogen, and 2 weeks of surgery or trauma history.The control group inclusion critera: Head CT examination revealed normal.The control group exclusion critera as same as SCI group.Testing and material Fasting blood 5ml of SCI group and the control group subjects was collected for the detection of serum levels of total bilirubin(TBIL), direct bilirubin(DBIL), indirect bilirubin(IBIL), total cholesterol(TC), riglyceride(TG), high density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C), homocysteine(t-HCY) fasting blood glucose(FBG),by Beckman automatic biochemical analyzer. Detailed asking of history, clinical data were recorded, including age, gender, blood pressure, blood glucose, smoking and drinking history, medications, past history and so on.Statistic analysis The data was analyzed using SPSS 17.0. Qualitative data were analyzed by t test. Qualitative data were analyzed by chi-square test. The significant indexes were analyzed by logistic regression analysis. The difference was statistically significant as P<0.05.Results1.There were no statistical difference in age, smoking history, drinking history, history of hypertension, history of diabetes, FBG, TG, HDL-C between SCI group and controlgroup(P>0.05).2.The participants with SCI had lower TB levels than those without SCI. The levels of total cholesterol, low-density lipoprotein, cholesterol and homocysteine in SCI group were significantly higher than those in control(P<0.05).3.These significant indexes served as independent variables. Multivariate logistic regression analysis indicated that bilirubin, blood lipid and homocysteine were the risk factors for SCI.ConclusionBilirubin is a novel biochemical indicator for SCI regardless of classical cardiovascular risk factors. The subjects with a low TB had higher prevalence of SCI. Early measurement of TB may be useful to assess the risk of SCI. Serum bilirubin, blood lipid and homocysteine were the risk factors for SCI..