| Purpose:through evaluate the clinical curative effect of the scheme to accept TCM Comprehensive regimen in the treatment of advanced non small cell lung cancer clinical data were retrospectively analyzed to explore the traditional Chinese medicine for the main body of the comprehensive treatment in the treatment of advanced non small cell lung cancer is effective and scientific in order to to the best fit period and population have an accurate positioning, for advanced non small cell lung cancer treatment mode for preliminary exploration, for Chinese medicine in the treatment of advanced non small cell lung cancer to provide reference.Methods:this topic as the case review study, from January 2013～December 2015 during, hospitalized in the Suzhou traditional Chinese Medicine Hospital of advanced non small cell lung cancer 1292 inpatients in, according to the case of inclusion and exclusion criteria,142 cases, statistics and analyses of cases generally, survival, entity tumor response evaluation, KPS score, lung cancer symptom integral and the course of treatment of adverse reactions, adverse events, and so on, at the same time, through the factor to influence the survival time of constructing single factor analysis model and multi factor risk model, was observed in the patients with different-clinical characteristics and analysis of the different degree of benefit.Results:1. Male and female prevalence ratio of 3:1, had a history of smoking and no smoking history of the proportion of patients prevalence ratio of 2.74:1, mean age 66.84+857 years,60 cases of type of deficiency of both qi and Yin, accounted for than 42.25%. The preliminary results suggest that advanced non small cell lung cancer patients with multiple previous have smoking history of elderly men and syndrome differentiation of traditional Chinese medicine to deficiency of both qi and Yin.2. after 1 cycle of integrated traditional Chinese medicine treatment, the lung cancer symptom integral treatment before falling to 4.49+3.39 PTS, before and after treatment (P< 0.001), with statistical significance, suggesting that the integrated TCM therapy is better to improve the effect of clinical symptoms. Each cycle and the treatment of KPS patients after scoring mostly stable and improving, a handful of decline, suggesting that patients well tolerated. All of the cases were adverse reactions and adverse events, suggesting that TCM treatment is with high safety mode of treatment.3. The subject case after accepting TCM Comprehensive regimen in the treatment of, and the average survival period 10.5+6.7 months, the median survival time was 7.2 months, with previous chemotherapy combined with comparison and were not obviously prolonged, which may and the subject into the cases of elderly patients with and KPS scores at baseline level is related to the low K-M survival in univariate analysis model initially speculated that:no smoking history, initial KPS score higher, to accept TCM Comprehensive regimen in the treatment cycle, solid tumor response evaluation for patients with SD, a relatively good prognosis. Survival time is prolonged observably; TCM differentiation is Qi stagnation and blood stasis in patients with good prognosis, the prognosis of patients with deficiency of both qi and Yin is the worst; early actively accept comprehensive treatment, the prognosis is good, and the survival time was significantly prolonged. COX multivariate analysis model, the survival period was 10 months or so, The risk of death is linear increase, especially after 15 months, the risk of death increased linearly. Treatment cycle, the previous treatment, the efficacy of four factors, such as the evaluation of statistical significance (P<0.05). Integrated risk function curve, treatment cycle. No prior standard treatment, evaluation of therapeutic efficacy of solid tumors for PD patients, death risk is corresponding to the increased significantly:accept less than three cycles of treatment in patients with the risk of death is much higher than that of patients who received six cycles; previously treated patients with western medicine treatment compared to only accept TCM Comprehensive regimen in the treatment of patients with a low 20%-50%; solid tumor response evaluation for patients with SD risk of death about evaluation for 53.7% of PD patients.4. With the increase of age, the curative effect has a trend of increasing, and cancer cells in elderly patients with slower growth rate have a certain relationship; patients with a history of smoking whether in the onset of non small cell lung cancer, or in the treatment and prognosis of the disease process have considerable influence; KPS score for evaluation of curative effect is significant, higher KPS score, curative effect is relatively good. There is a significant correlation between non small cell lung cancer (NSCLC) KPS score and survival, curative effect evaluation. Therefore, we in clinical practice should accurately and effectively detect and quality of life in patients with non small cell lung cancer, to improve the general condition and adverse symptoms, in the hope of more effective in the treatment of non small cell lung cancer.Conclusion:1. Advanced non small cell lung cancer patients with multiple previous have smoking history of elderly men and syndrome differentiation of traditional Chinese medicine to deficiency of both qi and Yin.2. TCM Comprehensive treatment is the treatment which with high safety mode, well tolerated in patients, and clinical symptoms, can improve the quality of life of patients.3. Without a prior history of smoking, higher KPS scores, more than the treatment cycle, solid tumor response evaluation of SD, TCM differentiation is Qi stagnation and blood stasis early actively accept comprehensive treatment of the risk of death in patients with relatively low, prognosis and clinical efficacy were better, survival significantly prolonged. |
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