TCM Syndrome Factors Of Chronic Heart Failure With Anemia

ObjectiveThis study focused on:1) the distribution of TCM syndrome factors of chronic heart failure with anemia.2) The relationship between physical and chemical parameters of each TCM syndrome factors; 3) Compared with Chronic Heart Failure to explore the difference of TCM syndrome factors between the two.MethodsThe study select 298 inpatients cases from the First Affiliated Hospital of Guangzhou Traditional Chinese Medicine University, in which 193 chronic heart failure with anemia patients,105 chronic heart failure patients. Collect general information of patients, four diagnostic information, physical and chemical indicators. General information includes:age, gender, functional class, mainly associated disease, the underlying disease, smoking history, drinking history, etc; Four diagnostic data using the "syndrome distinguish syndrome element scale" which was formulated by Professor Zhu Wenfeng; Physical and chemical indicators include brain natriuretic peptide (BNP), hemoglobin (HGB), red blood cell distribution width (RDW), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high density lipoprotein protein cholesterol (HDL-C), uric acid (UA), serum creatinine (Cr) albumin (ALB), etc.Results1. Disease location factors of chronic heart failure with anemia group prime focus:170 cases of lung (88%),158 cases of heart (82%),142 cases of kidney (74%),91 cases of spleen (47%),22 cases of liver (11%); Disease syndrome elements are mainly concentrated in:178 cases of qi deficiency (92%), 152 cases of Yang (79%),149 cases of anemia (77%),135 cases of sputum (70%), 120 cases of Yin (62%),96 cases of Stasis (50%),60 cases of drink evil (31%), 22 cases of qi stagnation (11%).2. The relationship between each syndrome elements of Chronic heart failure with anemia and physical and chemical indicators:2.1 Syndrome elements of disease location:193 cases of anemia in patients with chronic heart failure, according to whether the main syndrome elements divided into two groups, were the age, BNP, HGB, RBC, MCV, MCHC, MCH, RDW-CV, RDW-SD, PDW, HCT, CHOL, TG, LDL-C, CREA, UA, CysC, serum albumin, left ventricular end-diastolic diameter, left ventricular ejection fraction compared with the mood in which the syndrome known as heart comparison, CREA and CysC difference was statistically significant (P<0.05); pulmonary syndrome with no known lung comparison, RDW-CV and RDW-SD difference was statistically significant (P<0.05), CREA and TG significantly different (P <0.01); with the syndrome known as spleen asplenia comparison,in terms of age, HGB, RBC, HCT, CREA, ALB, TB, CysC were significantly different (P<0.01); compared with the syndrome known as liver without liver, PDW difference was statistically significant (P<0.05); renal syndrome with no known kidney compared to the HGB, RBC, HCT, CREA, ALB, on CysC were significantly different (P<0.01).2.2 Disease resistance syndrome factor:no certificate is known as phlegm and sputum compared with no significant difference (P> 0.05); compared with the syndrome known drink no drink in BNP (P<0.05), left ventricular ejection fraction (P<0.01 the difference) was statistically significant; syndrome known as qi stagnation and stagnation compared to airless, PDW difference was statistically significant (P<0.01); no blood stasis and blood stasis syndrome known as compared to the difference was not significant statistically significant (P> 0.05); Qi deficiency syndrome known as qi deficiency and no comparison, RBC, CysC, the ALB difference was statistically significant (P <0.05); with the syndrome known as deficiency anemia compared, HGB, RBC on HCT, CREA, CysC were significantly different (P<0.01); and no Yang Yang Su syndrome compared various indicators showed no significant difference; and no yin deficiency syndrome elements compared to the MCHC significant difference (P<0.01), the CREA, UA, CysC have significant difference (P<0.05).2.3 Compairs in which the disease Slip prime spleen, kidney disease and sex hormone deficiency syndrome, Yin Logistics multivariate regression analyzes, independent factors Spleen elements are:HGB, RBC; independent predictors of renal syndrome factors are:ALB; deficiency syndrome elements of each indicator was no significant correlation; independent factor deficiency syndrome factors are:MCHC, UA.3. Chronic heart failure and chronic heart failure with anemia group group basic information and physical and chemical indicators, gender, age, no significant difference in the comparison; in BNP, CREA, CysC chronic heart failure and chronic anemia group were higher than HF group, the difference was statistically significant (P<0.05); in the HGB, PDW, ALB, TB chronic heart failure group than in chronic heart failure and anemia group, the difference was statistically significant (P<0.05).4. Comparison of two elements in TCM, from the frequency distribution, the group with chronic heart failure syndrome elements of disease location in the frequency of heart, lung, kidney-based, chronic heart failure and anemia group is still involved in the spleen; two solid Syndrome Su compared to sputum chronic heart failure, drink, blood stasis based, chronic heart failure and anemia group with phlegm, blood stasis based; two prime Deficiency Syndrome compared with chronic heart failure group qi, Yang, the main deficiency, chronic heart failure and anemia deficiency Syndrome group of four factors were higher proportion than the column; syndrome elements from two points of view comparison, chronic heart failure and anemia group elements and blood in the spleen, kidney syndrome stasis, blood deficiency syndrome elements were higher than on chronic heart failure group, the difference was statistically significant (P<0.05); chronic heart failure in the Shanghai and Susan Su Yin deficiency anemia points higher than the group with chronic heart failure, the difference was statistically significant (P<0.05).Conclusion:1.193 cases of anemia in patients with chronic heart failure and major disease Slip known lung, heart, spleen, kidney, disease of the main factors Qi, Yang, blood, phlegm, deficiency, blood stasis.2.1 The main syndrome elements of 193 chronic heart failure with anemia and and physical and chemical indicators of disease Slip Susan and CREA, CysC relevant; lung disease Slip prime and RDW-CV, RDW-SD, CREA, TG relevant; syndrome element spleen and age, HGB, RBC, HCT, CREA, ALB, TB, CysC relevant; liver disease Slip and PDW-related factors; and kidney disease Slip prime HGB, RBC, HCT, CREA, ALB, CysC relevant; wherein HGB, ALB independent factors for the sick Slip prime kidney; independent factors for the disease Slip RBC prime spleen.2.2 Disease syndrome elements:drink evil and BNP, LVEF correlation; qi stagnation syndrome elements of disease associated with PDW; disease of qi deficiency syndrome elements and RBC, CysC, ALB correlation; disease of hormone deficiency syndrome and HGB, RBC, HCT, CREA, CysC correlation; disease of hormone deficiency syndrome with age, MCHC, CREA, UA, CysC relevant; MCHC, UA independent factors of disease syndrome factor Yin; hormone deficiency syndrome showed no significant correlation with the sex.3. Chronic heart failure with anemia group slower heart failure syndrome elements of disease location in the group, in addition to heart, lung, kidney, the spleen is still involved; from the spleen, kidney-based; disease resistance syndrome elements in places Deficiency Syndrome main elements, solid elements places phlegm syndrome, blood stasis mainly by blood stasis, blood deficiency.