Detecting The Best Dosage Interval Time Of Sufentanil And Etomidate During The Painless Stomach And Colonoscopy Anesthesia

Objective: To study and compare when patients were injected with sufentanil, the impacts of etomidate injected interval times on anesthesia and myoclonus, and to detect the best dosage interval time of sufentanil and etomidate used in the painless stomach and colonoscopy anesthesia. Methods: We chose 160 ASA Ⅰ-Ⅱpatients who volunteered to accept painless stomach or colonoscopy examination, and randomly divided them into A, B, C and D four groups. We observed and recorded the patients basic vital signs before painless stomach or colonoscopy examination, and drawed 2ml patients’ blood. Every patient was given 0.1μg/kg sufentanil and the first dose of 0.15-0.2mg/kg etomidate in 30 seconds, the difference was the injection intervals of two drugs among four groups. The patients of group A were injected with sufentanil, then treated with etomidate in 0-2min, the patients of group B were injected with sufentanil, then given with etomidate in 2-5min, the patients of group C were injected with sufentanil, then treated with etomidate in 5-10 min, the patients of group D were injected with sufentanil, then treated with etomidate 10 minites later. We observed and recorded the patients’ basic vital signs, the lowest blood pressure, heart rate, blood oxygen saturation, the dosage of sufentanil and etomidate, muscle fibrillation, operation time, the time of opening eyes, the reaction to tendoscopy, the body dynamic response, frowning and the side effects of this two drugs, and drawn 2ml patients’ blood for testing their cold blood lactate after this operation. Results: The results shown that the Blood Pressure(BP) and Heart Rate(HR) of each group were both declined after using the two drugs, and the systolic blood pressure decreased by 14.1%-18.3% compared to the basic vital sign before injected with drugs, but it didn’t reach the diagnostic criteria of hypotension(less than 20% of the basis). The patients with heart rate decreased by 9.1%- 10.7% were the normal range. There were not statistically significant of the BP and HR between the four groups. The changes of SpO2 in each group was slight, showing the respiratory inhibition effect was lesser, there were not statistically significant between the four groups(P>0.05). The myoclonus incidence rates of four groups were 57.5%, 40%, 62.5%, 35% respectively(P<0.05). There were no differences about the reaction to tendoscopy, the body dynamic response, frowning, the dose of anesthetic, operation time and the time of opening eyes among the four groups(P>0.05). There were 11 cases(27.5%) of group A, 10 cases(25%) of group B, 15 cases(37.5%) of group C and 25 cases(62.5%) of group D appeared some side effects such as dizziness, nausea, vomiting, and the difference was meaningful(P<0.05). Conclusions: During the anesthesia of painless stomach and colonoscopy, after the injection of sufentanil, then giving the patients etomidate in 2-5 min will get the best preventation effect of myoclonus, the light inhibition of breathing and circulation, the strong inhibition of stimulation to tendoscopy, the light degree of body dynamic response and frowning, and the low incidence rate of side effects, and the patients will revive rapidly and feel good.