Prognostic Significance Of Inflammation-based Prognostic Scores In Patients With Clear Cell Renal Cell Carcinoma

Aim: Plenty of studies have demonstrated the prognostic value of various inflammation-based prognostic scores in cancer patients. We undertook a retrospective analysis to evaluate the C-reactive protein/ albumin ratio(CAR) and the albumin to globulin ratio(AGR) for their prognostic value in patients with clear cell renal cell carcinoma(CCRCC).Methods: The study comprised 461 localized and locally advanced RCC patients undergoing nephrectomy between 2003 and 2012 in our hospital. We evaluated the associations of CAR and AGR with clinicopathological characteristics and overall survival(OS). In addition, we proposed a nomogram combined the inflammation-based prognostic scores with clinicopathological characteristics.Results: CAR and AGR were significantly associated with clinicopathological characteristics and both served as independent prognostic factors for OS of CCRCC patients. Generally speaking, compared with those established inflammation-based prognostic scores, CAR and AGR showed better predictive accuracy. By incorporating the inflammation-based prognostic scores in traditional staging systems, a nomogram was constructed and performed well.Conclusion: CAR and AGR are both promising indicators to predict OS of CCRCC patients. Incorporating the inflammation-based prognostic scores in traditional staging systems, our nomogram showed better predictive accuracy.