| Objective:To analyze the variation of bilirubin level and occurrence of hyperbilirubinemia among normal neonates and newborns with G-6-PD deficiency, clinical features of G-6-PD deficiency and the relation with hyperbilirubinemia, which helps in early diagnosis, timely treatment, and decrease incidence of bilirubin encephalopathy.Methods:173 cases were enrolled from December 2014 through December 2015, in the neonatal department of Pediatrics of the first affiliated hospital of Guangxi Medical University. All patients were full term or post-term infants, with the age< 12 hours, and were divided into G6PD deficiency group and normal group. Their levels of bilirubin were recorded for within 7 days after birth, the observation process, such as children reach the standard phototherapy immediately to the intervention. Recorded and compared each group time jaundice appears, jaundice peak time, peak serum bilirubin, hyperbilirubinemia incidence, frequency of treatment, with or without complications, and statistical analysis.Results:(1) incidence of hyperbilirubinemia in G6PD deficiency group was higher than the G6PD normal group, there were no incidence of bilirubin encephalopathy in either group. (2) Non hyperbilirubinemia of newborn G6PD lack group and the normal group age bilirubin values compared were significant differences (P< 0.05) in each time period of bilirubin in G6PD deficient group were significantly higher than those in the normal group; (3) of neonates with hyperbilirubinemia G6PD lacking group and the normal group age bilirubin value and bilirubin values had significant difference (P<0.05), G6PD deficiency group were significantly higher than those in the normal group. (4) The occurrence time of jaundice in Severe G6PD deficiency, moderate G6PD deficiency, mild G6PD deficiency, G6PD normal newborn was 12 hours,12 hours, 24 hours,24 hours; peak time was 2 days,3 days,4 days,4 days, respectively; peak values were 242.35±42.03 umol/L,232.35±42.03 umol/L,216.54±19.14umol/L,206.12±25.06 umol/L, fade time of jaundice was 6 days,6days,5.5 days,5 days, respectively; (5) Severe G6PD deficiency, moderate G6PD deficiency, mild G6PD deficiency, there were significant differences (P<0.05) between G6PD normal newborn serum bilirubin value reached during phototherapy, severe G6PD deficiency bilirubin reaches the intervention group when 36.74±20.49 hours there are significant differences of phototherapy times among each group (P<0.05), severe G6PD deficiency group required phototherapy maximum number of (3.31±1.19) times.Conclusions:.1 G6PD deficiency is one of the causes of neonatal hyperbilirubinemia in Guangxi area.2.G6PD deficient group of neonatal hyperbilirubinemia regardless of whether, when age was higher than that of G6PD normal neonatal bilirubin.3.G6PD lack of neonatal birth 12 hours after the beginning of the rise of bilirubin, the intervention criteria for more than 9 thousand and 500 points above the time as early as third days after birth, as early as G6PD normal newborn.4.G6PD levels of enzyme activity and bilirubin values were negatively correlated, G6PD severe deficiency of newborns after 2 days of bilirubin values up to 95 percentile or above; G6PD moderate deficiency neonates born after 3 days of bilirubin values up to 75 percentile or above; G6PD mild deficiency neonates and normal control group of neonatal similar, after 4 days of serum bilirubin value value is 40 percent.5. Fixed treatment, G6PD deficiency neonatal phototherapy times more than in newborn infants with normal G6PD. The course of treatment was longer than that of G6PD normal neonates. |
PDF Full Text Request