| Objective:To explore the clinical manifestation, treatment methods, therapeutic efficacy and outcomes of soft tissue osteosarcoma..Methods:The clinical records and follow-up information of 10 patients with soft tissue osteosarcoma admitted in Department of Orthopedics, The xxxx Affiliated Hospital of Zhejiang University School of Medicine from January 2002 to December 2014 were retrospectively analyzed.Results:Of 10 patients with soft tissue osteosarcoma, six were male, and four were female,7 patients had tumors located in limbs, and 3 had tumors located in groin, ilium and hip,respectively;7 tumor lesions were located in superficial layer of deep fascia and 3were located in deep layer, concerning tumor size, the tumor diameter was larger than 10 cm in 4cases,5-10 in 4cases,and shorter than 5 cm in 2 cases, regarding to pathologic grading,9 cases were high-grade osteosarcoma, and 1 case was low to medium grade。 All patients underwent tumor resection, of which,4 cases received postoperative chemotherapy, and radiotherapy was not utilized.Three cases suffered from local recurrence in which,4 cases also had distant metastasis, no metastasis alone was observed. Four cases died of lung metastasis.Conclusion:Soft tissue osteosarcoma is characterized by low morbidity, high malignancy grade, high local recurrence rate and distant metastasis rate, as well as high mortality. Extensive resection is the most important therapeutic strategy for soft tissue osteosarcoma, and its outcomes are related to resection extent and tumor size. Chemotherapy is not a validated treatment strategy, and radiotherapy is also seldom utilized in treatment of soft tissue osteosarcoma. |
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